Biophysical properties and regulation of GABAA receptor channels
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.contributor.author | Twyman, Roy E. | en_US |
dc.date.accessioned | 2006-04-10T14:42:05Z | |
dc.date.available | 2006-04-10T14:42:05Z | |
dc.date.issued | 1991-06 | en_US |
dc.identifier.citation | Macdonald, Robert L., Twyman, Roy E. (1991/06)."Biophysical properties and regulation of GABAA receptor channels." Seminars in Neuroscience 3(3): 219-230. <http://hdl.handle.net/2027.42/29298> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WX5-4DVV2NV-6/2/06295a5fd73caa727a8cf09505302a92 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29298 | |
dc.description.abstract | When GABA binds to the GABAA receptor, bursts of chloride ion channel openings occur, resulting in membrane hyperpolarization. Barbiturates increase current by increasing mean channel open time, and the convulsant drug picrotoxin decreases current by decreasing mean channel open time. The two drugs bind to allosterically coupled sites on the receptor to regulate channel gating. Benzodiazepines increase and [beta]-carbolines decrease channel opening frequency by binding to the benzodiazepine receptor on GABAA receptor channels. Neurosteroids increase current by increasing mean channel open time and opening frequency, possibly by interacting with a specific site on the GABAA receptor. The convulsant drug penicillin reduces current by producing open channel block. The GABAA receptor subunits contain consensus sequences for phosphorylation by cAMP-dependent kinase, C kinase and tyrosine kinase. The functional consequences of receptor phosphorylation remain unclear. In future studies the use of molecular biological and single channel recording techniques should allow characterization of the properties of GABAA receptor channels, the role of receptor phosphorylation and the specific mechanisms of actions of regulatory drugs. | en_US |
dc.format.extent | 1054564 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Biophysical properties and regulation of GABAA receptor channels | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From the Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104, USA; From the Department of Physiology, University of Michigan Medical Center, Ann Arbor, MI 48104, USA | en_US |
dc.contributor.affiliationum | From the Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48104, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29298/1/0000361.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/1044-5765(91)90019-K | en_US |
dc.identifier.source | Seminars in Neuroscience | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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