View Item 

Show simple item record

Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene
dc.contributor.authorSeasholtz, Audrey F.en_US
dc.contributor.authorBourbonais, Francis J.en_US
dc.contributor.authorHarnden, Catherine E.en_US
dc.contributor.authorCamper, Sally A.en_US
dc.date.accessioned2006-04-10T14:42:12Z
dc.date.available2006-04-10T14:42:12Z
dc.date.issued1991-06en_US
dc.identifier.citationSeasholtz, Audrey F., Bourbonais, Francis J., Harnden, Catherine E., Camper, Sally A. (1991/06)."Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene." Molecular and Cellular Neuroscience 2(3): 266-273. <http://hdl.handle.net/2027.42/29301>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WNB-4DXB5W1-1J/2/748b571c43c2fd643515d3caea682a94en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29301
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=19912808&dopt=citationen_US
dc.description.abstractThe mouse corticotropin-releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human, rat, and ovine genes with two exons and an intervening sequence of 675 base pairs interrupting the 5' untranslated sequence of the mature mRNA. Analysis of the nucleotide sequence reveals that the mouse CRH peptide is identical at the amino acid level to the human and rat CRH peptides, with only three nucleotide changes between the rat and mouse sequences within the CRH peptide-encoding region. Additionally, the mouse CRH gene exhibits greater than 92% homology to the rat, human, and ovine CRH genes within the first 336 nucleotides of 5' flanking DNA, suggesting that this sequence contains important transcriptional control elements which have been conserved across species to mediate the regulation of this important neuroendocrine peptide. The expression of the mouse CRH gene in brain is demonstrated using in situ hybridization analysis. Mouse CRH mRNA can be detected in the paraventricular nucleus of the hypothalamus and inferior olivary nucleus of mouse brain.en_US
dc.format.extent5947633 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleNucleotide sequence and expression of the mouse corticotropin-releasing hormone geneen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA; Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid19912808en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29301/1/0000364.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/1044-7431(91)90054-Ren_US
dc.identifier.sourceMolecular and Cellular Neuroscienceen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000364.pdf
Size:
5.672MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.