CSF monoamine metabolites and somatostatin in Alzheimer's disease and major depression
dc.contributor.author | Molchan, Susan E. | en_US |
dc.contributor.author | Lawlor, Brian A. | en_US |
dc.contributor.author | Hill, James L. | en_US |
dc.contributor.author | Martinez, Rick A. | en_US |
dc.contributor.author | Davis, Candace L. | en_US |
dc.contributor.author | Mellow, Alan M. | en_US |
dc.contributor.author | Rubinow, David R. | en_US |
dc.contributor.author | Sunderland, Trey | en_US |
dc.date.accessioned | 2006-04-10T14:42:53Z | |
dc.date.available | 2006-04-10T14:42:53Z | |
dc.date.issued | 1991-06-01 | en_US |
dc.identifier.citation | Molchan, Susan E., Lawlor, Brian A., Hill, James L., Martinez, Rick A., Davis, Candace L., Mellow, Alan M., Rubinow, David R., Sunderland, Trey (1991/06/01)."CSF monoamine metabolites and somatostatin in Alzheimer's disease and major depression." Biological Psychiatry 29(11): 1110-1118. <http://hdl.handle.net/2027.42/29318> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4S-484N7B0-JP/2/e1005b62eed5693769fae19d077d43b9 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29318 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1714776&dopt=citation | en_US |
dc.description.abstract | Decreased cerebrospinal fluid (CSF), somatostatinlike immunoreactivity (SLI) and alterations in the CSF monamine metabolites 3-methoxy-4-hydroxyphenylethylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA) have been reported in patients with probable Alzheimer's disease (AD) and in patients with major depression. In this study, we found CSF SLI to be significantly lower in a large group of AD patients n = 60) and in a group of age-matched patients with major depression (n = 18) as compared with normal controls (n = 12). Mean CSF, MHPG, 5-HIAA, andHVA levels were not significantly different among diagnostic groups. Within a group of "depressed" AD patients, CSF levels of 5-HIAA showed a significant positive correlation (p = 0.03) with CSF SLI; a similar relationship was found within the group of patients with major depression. Further exploration of the relationship between the somatostatin and serotonin systems may provide clues as to how neuropeptides interact with monoamine neurotransmitters and what role they have in depression. | en_US |
dc.format.extent | 775042 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | CSF monoamine metabolites and somatostatin in Alzheimer's disease and major depression | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Division of Geropsychiatry, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Section on Behavioral Endocrinology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Section on Behavioral Endocrinology, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Unit on Geriatric Psychopharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA | en_US |
dc.identifier.pmid | 1714776 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29318/1/0000383.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-3223(91)90253-I | en_US |
dc.identifier.source | Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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