Effects of age on diabetes- and insulin-induced changes in pancreatic levels of [alpha]-amylase and its mRNA
dc.contributor.author | Kim, Sun-Kee | en_US |
dc.contributor.author | Cuzzort, Louan M. | en_US |
dc.contributor.author | Allen, Edward D. | en_US |
dc.date.accessioned | 2006-04-10T14:44:04Z | |
dc.date.available | 2006-04-10T14:44:04Z | |
dc.date.issued | 1991-05 | en_US |
dc.identifier.citation | Kim, Sun-Kee, Cuzzort, Louan M., Allen, Edward D. (1991/05)."Effects of age on diabetes- and insulin-induced changes in pancreatic levels of [alpha]-amylase and its mRNA." Mechanisms of Ageing and Development 58(2-3): 151-161. <http://hdl.handle.net/2027.42/29348> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T31-47VJYK6-83/2/a41ef224ddca7174f4b504ecad31ea13 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29348 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1875725&dopt=citation | en_US |
dc.description.abstract | During aging, protein synthesis undergoes decremental changes in many organs and tissues. In the pancreas, as well as in other exocrine glands, the rate of protein synthesis declines with age. However, it is unknown whether this decline is related to intrinsic aging changes which affect the secretory cell function. In this study, we compared the ability of pancreatic acinar cells to synthesize amylase and its messenger RNA (mRNA) in response to insulin treatment of young and old rats rendered diabetic with streptozotocin (STZ). In STZ-induced diabetic rats, amylase protein and its mRNA levels were reduced drastically in the pancreas of young and old groups. Injections of these diabetic rats with insulin increased pancreatic amylase mRNA contents significantly in both young and old rats. Insulin also increased proportions of amylase protein synthesis in the pancreas of both age groups. These results indicate that the pancreatic cells remain effective during aging in their transcriptional activity for functional amylase mRNA in response to an exogenous stimulus of insulin. | en_US |
dc.format.extent | 585255 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effects of age on diabetes- and insulin-induced changes in pancreatic levels of [alpha]-amylase and its mRNA | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Research Service, V.A. Medical Center, Ann Arbor, MI 48105, U.S.A.; Anatomy and Cell Biology, Medical School, Ann Arbor, MI, U.S.A.; Biologic and Material Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Anatomy and Cell Biology, Medical School, Ann Arbor, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Research Service, V.A. Medical Center, Ann Arbor, MI 48105, U.S.A. | en_US |
dc.identifier.pmid | 1875725 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29348/1/0000416.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0047-6374(91)90089-I | en_US |
dc.identifier.source | Mechanisms of Ageing and Development | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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