Isolation, characterization, and chromosomal mapping of mouse P450 17[alpha]-hydroxylase/C17-20 lyase
dc.contributor.author | Youngblood, Geri L. | en_US |
dc.contributor.author | Sartorius, Carol | en_US |
dc.contributor.author | Taylor, Benjamin A. | en_US |
dc.contributor.author | Payne, Anita H. | en_US |
dc.date.accessioned | 2006-04-10T14:44:31Z | |
dc.date.available | 2006-04-10T14:44:31Z | |
dc.date.issued | 1991-05 | en_US |
dc.identifier.citation | Youngblood, Geri L., Sartorius, Carol, Taylor, Benjamin A., Payne, Anita H. (1991/05)."Isolation, characterization, and chromosomal mapping of mouse P450 17[alpha]-hydroxylase/C17-20 lyase." Genomics 10(1): 270-275. <http://hdl.handle.net/2027.42/29359> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DP5JB1-18/2/523c5f63f6620ee3cbc99746922c7f48 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29359 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1840559&dopt=citation | en_US |
dc.description.abstract | Cytochrome P450 17[alpha]-hydroxylase/C17-20 lyase (P45017[alpha]) catalyzes the conversion of C-21 steroids to C-19 steroids in gonads. A full-length mouse cDNA encoding P45017[alpha] was isolated from a mouse Leydig cell library and characterized by restriction mapping and sequencing. The predieted amino acid sequence has 83% homology to rat, 66% homology to human, and 62% homology to bovine P45017[alpha] amino acid sequences. The protein is 507 amino acids in length, which is 1 amino acid shorter than the human protein and 2 amino acids shorter than the bovine protein. The structural gene encoding P45017[alpha] (Cyp17) was localized utilizing an interspecific testcross to mouse chromosome 19, distal to Got-1. Another cytochrome P450, P4502c (Cyp2c), also is located at the distal end of chromosome 19. CYP17, CYP2c, and GOT1 have been mapped to human chromosome 10, with CYP2C and GOT1 mapped to the distal region, q24.3 and q25.3, respectively. The data in the present study indicate conserved syntenic loci on mouse chromosome 19 and human chromosome 10 and predict that the structural gene encoding P45017[alpha] will be found distal to GOT1 on human chromosome 10. | en_US |
dc.format.extent | 849660 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Isolation, characterization, and chromosomal mapping of mouse P450 17[alpha]-hydroxylase/C17-20 lyase | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, The University of Michigan, Ann Arbor, Michigan 48109-0278, USA | en_US |
dc.contributor.affiliationum | Department of Obstetrics and Gynecology, The University of Michigan, Ann Arbor, Michigan 48109-0278, USA; Department of Biological Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-0278, USA. | en_US |
dc.contributor.affiliationother | The Jackson Laboratory, Bar Harbor, Maine 04609, USA | en_US |
dc.identifier.pmid | 1840559 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29359/1/0000427.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(91)90511-C | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.