Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model
dc.contributor.author | Wakefield, Thomas W. | en_US |
dc.contributor.author | Wrobleski, Shirley K. | en_US |
dc.contributor.author | Wirthlin, Douglas J. | en_US |
dc.contributor.author | Wang, Thomas W. | en_US |
dc.contributor.author | Stanley, James C. | en_US |
dc.date.accessioned | 2006-04-10T14:44:46Z | |
dc.date.available | 2006-04-10T14:44:46Z | |
dc.date.issued | 1991-05 | en_US |
dc.identifier.citation | Wakefield, Thomas W., Wrobleski, Shirley K., Wirthlin, Douglas J., Wang, Thomas W., Stanley, James C. (1991/05)."Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model." Journal of Surgical Research 50(5): 449-456. <http://hdl.handle.net/2027.42/29365> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNG3TV-11K/2/2ec5fc181e7a6f4783d9e65035322ee9 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29365 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2038184&dopt=citation | en_US |
dc.description.abstract | Prostanoid activity was correlated with the hemodynamic effects of protamine sulfate reversal of heparin in 24 dogs undergoing three different pretreatment regimens: Group I (n = 8) received saline, Group II (n = 8) received the thromboxane synthetase inhibitor U63,557A (30 mg/kg), and Group III (n = 8) received indomethacin (10 mg/kg). Pretreatment substances were administered as 5-min intravenous infusions 20 min before anticoagulation with intravenous heparin (150 IU/kg). Protamine sulfate (1.5 mg/kg) was subsequently given as a 10-sec intravenous infusion 30 min after heparin had been administered. Hemodynamic data, as well as prostacyclin (PGI2) and thromboxane (TxA2) activity in aortic, venous, and pulmonary artery blood samples, were assessed over a 30-min time period following protamine administration. Group III indomethacin pretreatment provided the most protection from declines in blood pressure, heart rate, cardiac output, venous oxygen saturation, oxygen consumption, and elevations in pulmonary pressures and was accompanied with actual declines in PGI2. Group II U63,557A pretreatment was associated with the most severe hemodynamic changes and the greatest increase in PGI2 (+576%). Elevated PGI2 correlated with hypotension at 1 and 3 min (P 2 changes did not correlate with hemodynamic changes. Protamine's adverse hemodynamic responses were attenuated with cyclooxygenase blockade by indomethacin, but were worsened with selective TxA2 blockade with U63,557A. Excess arachadonic acid precursors in the latter setting may increase PGI2 production. This study, for the first time, raises the possibility that PGI2 contributes to the adverse effects accompanying protamine reversal of heparin anticoagulation. | en_US |
dc.format.extent | 893378 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Jobst Vascular Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Jobst Vascular Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Jobst Vascular Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Jobst Vascular Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Section of Vascular Surgery, Jobst Vascular Research Laboratories, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.identifier.pmid | 2038184 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29365/1/0000434.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(91)90023-F | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.