Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions
dc.contributor.author | Dulon, Didier | en_US |
dc.contributor.author | Zajic, Gary | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.date.accessioned | 2006-04-10T14:47:26Z | |
dc.date.available | 2006-04-10T14:47:26Z | |
dc.date.issued | 1991-03 | en_US |
dc.identifier.citation | Dulon, D., Zajic, G., Schacht, J. (1991/03)."Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions." Hearing Research 52(1): 225-231. <http://hdl.handle.net/2027.42/29432> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-485H32M-1R/2/6dc43adc88539a3682948108ae4cef85 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29432 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2061210&dopt=citation | en_US |
dc.description.abstract | Inner and outer hair cells were mechanically isolated from the guinea pig cochlea and subjected to stimuli known to induce shape changes in outer hair cells. Depolarization by 70 mM KCl which causes osmotic swelling of outer hair cells also swelled inner hair cells by approximately 8% of their volume. The application of the calcium ionophore ionomycin which induces cortical contractions and elongation of outer hair cells, did not affect the shape of inner hair cells. Since ionomycin increased free intracellular calcium levels in both inner and outer hair cells, the results demonstrate that inner hair cells do not possess the mechanisms necessary for a contractile response to calcium. Thus, calcium is a specific regulator of outer hair cell motility making this mechanism a likely physiological modulator of a transduction feedback process. | en_US |
dc.format.extent | 687879 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, The University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2061210 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29432/1/0000513.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(91)90202-K | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.