The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality
dc.contributor.author | Trujillo, Keith A. | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.date.accessioned | 2006-04-10T14:47:52Z | |
dc.date.available | 2006-04-10T14:47:52Z | |
dc.date.issued | 1991-03 | en_US |
dc.identifier.citation | Trujillo, Keith A., Akil, Huda (1991/03)."The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality." Pharmacology Biochemistry and Behavior 38(3): 673-675. <http://hdl.handle.net/2027.42/29443> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0N-479KP36-1WJ/2/dc3b02410481c5c5c00918e15a28bd4a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29443 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1829839&dopt=citation | en_US |
dc.description.abstract | Interactions between excitatory amino acids and opioids were examined by studying the ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to affect morphine catalepsy and lethality. MK-801 (0.3 mg/kg) reduced the ED50 for morphine-induced catalepsy from approximately 30 mg/kg to less than 10 mg/kg, and reduced the LD50 for morphine from approximately 100 mg/kg to approximately 10 mg/kg. Lower doses of MK-801 did not affect morphine catalepsy or lethality. MK-801, in the absence of morphine, produced no catalepsy or lethality at doses up to 3.0 mg/kg; at 0.3 mg/kg MK-801 caused weaving, body rolling and ataxia, as previously described, while at 3.0 mg/kg animals appeared to lose muscle tone, becoming limp. These results demonstrate that blockade of NMDA receptors can dramatically potentiate morphine catalepsy and lethality, and suggest a potential dangerous interaction with opioids in the clinical use of NMDA receptor antagonists. | en_US |
dc.format.extent | 309268 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, The University of Michigan 205 Washtenaw Place, Ann Arbor, MI 48109-0720, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, The University of Michigan 205 Washtenaw Place, Ann Arbor, MI 48109-0720, USA | en_US |
dc.identifier.pmid | 1829839 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29443/1/0000525.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0091-3057(91)90032-W | en_US |
dc.identifier.source | Pharmacology Biochemistry and Behavior | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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