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Pro-opiomelanocortin mRNA and peptide co-expression in the developing rat pituitary
dc.contributor.authorKhachaturian, Henryen_US
dc.contributor.authorKwak, Seung P.en_US
dc.contributor.authorSchafer, Martin K.-H.en_US
dc.contributor.authorWatson, Stanley J.en_US
dc.date.accessioned2006-04-10T14:49:12Z
dc.date.available2006-04-10T14:49:12Z
dc.date.issued1991-02en_US
dc.identifier.citationKhachaturian, Henry, Kwak, Seung P., Schafer, Martin K. -H., Watson, Stanley J. (1991/02)."Pro-opiomelanocortin mRNA and peptide co-expression in the developing rat pituitary." Brain Research Bulletin 26(2): 195-201. <http://hdl.handle.net/2027.42/29476>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6SYT-485RNGH-10H/2/d27c41c12bd8bb44868bb0b72ecbfc96en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29476
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1849441&dopt=citationen_US
dc.description.abstractPro-opiomelanocortin (POMC) is synthesized in both the pituitary gland and the brain. Various peptide products of this precursor, namely beta-endorphin, ACTH and alpha-MSH are co-localized in the anterior lobe corticotrophs, all intermediate lobe cells and in hypothalamic neurons. Messenger RNA (mRNA) for POMC has further been shown to exist in these tissues. In this study, we have shown that POMC mRNA, and peptide accumulation as detected by in situ hybridization and immunocytochemistry, respectively, occur simultaneously within the rat pituitary gland during ontogeny and that their maturation occurs in parallel during prenatal and early postnatal development.en_US
dc.format.extent1095761 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePro-opiomelanocortin mRNA and peptide co-expression in the developing rat pituitaryen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, 205 Washtenaw Place, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, 205 Washtenaw Place, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan, 205 Washtenaw Place, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherNeuroimaging and Applied Neuroscience Research Branch, National Institute of Mental Health Suite 11-105, 5600 Fishers Lane, Rockville, MD 20857, USAen_US
dc.identifier.pmid1849441en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29476/1/0000562.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0361-9230(91)90226-Aen_US
dc.identifier.sourceBrain Research Bulletinen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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