Trabecular bone remodeling: An experimental model
dc.contributor.author | Goldstein, Steven A. | en_US |
dc.contributor.author | Matthews, Larry S. | en_US |
dc.contributor.author | Kuhn, Janet L. | en_US |
dc.contributor.author | Hollister, Scott J. | en_US |
dc.date.accessioned | 2006-04-10T14:52:20Z | |
dc.date.available | 2006-04-10T14:52:20Z | |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Goldstein, Steven A., Matthews, Larry S., Kuhn, Janet L., Hollister, Scott J. (1991)."Trabecular bone remodeling: An experimental model." Journal of Biomechanics 24(Supplement 1): 135-150. <http://hdl.handle.net/2027.42/29555> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T82-4C2RSV6-H/2/f7eeaad39d7f26c100a650eea0f807fe | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29555 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1791174&dopt=citation | en_US |
dc.description.abstract | An experimental model, capable of inducing controlled stress fields to the distal femoral metaphyses of large dogs, is presented. This model utilized an implantable hydraulic device incorporating five loading cylinders and platens in direct contact with an exposed plane of trabecular bone. A microprocessor controls the loading characteristics, and finite element models were created to calculate the induced stress and strain fields. The trabecular remodeling response is measured using serial in vivo computed tomography, in vitro microcomputed tomography, and histologic analysis. The results of the experiment indicate that significant remodeling can be induced by the activated implant. An increase in trabecular orientation toward the loaded platens was observed, and a statistically significant decrease in connectivity was documented. The greatest effect was associated with a change in the loading rate. A fast rise time (70 ms) loading waveform induced significant bone ingrowth at the implant interface when compared to a slow rise time waveform (700 ms), and demonstrated high correlations with the calculated stress fields as remodeling approached an equilibrium state. | en_US |
dc.format.extent | 1601970 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Trabecular bone remodeling: An experimental model | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, The University of Michigan, Section of Orthopaedic Surgery, Department of Surgery, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, The University of Michigan, Section of Orthopaedic Surgery, Department of Surgery, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, The University of Michigan, Section of Orthopaedic Surgery, Department of Surgery, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Orthopaedic Research Laboratories, The University of Michigan, Section of Orthopaedic Surgery, Department of Surgery, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 1791174 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29555/1/0000643.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0021-9290(91)90384-Y | en_US |
dc.identifier.source | Journal of Biomechanics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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