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A rapid high yield synthesis of no-carrier-added (-)-[123I]iodocyanopindolol
dc.contributor.authorVan Dort, Marcian E.en_US
dc.contributor.authorGildersleeve, David L.en_US
dc.contributor.authorWieland, Donald M.en_US
dc.date.accessioned2006-04-10T14:54:01Z
dc.date.available2006-04-10T14:54:01Z
dc.date.issued1991en_US
dc.identifier.citationVan Dort, Marcian E., Gildersleeve, David L., Wieland, Donald M. (1991)."A rapid high yield synthesis of no-carrier-added (-)-[123I]iodocyanopindolol." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 42(3): 309-311. <http://hdl.handle.net/2027.42/29597>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6X3S-46Y3N7D-17S/2/b46c38ef3b342a59eb5f479a3abe0804en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29597
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1676024&dopt=citationen_US
dc.description.abstractA convenient and efficient radiosynthesis of no-carrier-added [123I]labeled (-)iodocyanopindolol, (-)-[123I]ICYP, a high affinity [beta] adrenergic antagonist, is described. (-)-[123I]ICYP was synthesized by a modified chloramine-T radioiodination of (-)cyanopindolol followed by a novel reversed-phase HPLC purification that provided the radiopharmaceutical as a directly injectable solution. The total synthesis time was typically less than 45 min and provided (-)-[123I]ICYP in a 59% radiochemical yield (not corrected for decay). In view of its high affinity for the [beta] adrenergic receptor, (-)-[123I]ICYP is a potentially useful probe for SPECT evaluation of cardiac adrenergic receptor density.en_US
dc.format.extent339165 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleA rapid high yield synthesis of no-carrier-added (-)-[123I]iodocyanopindololen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.identifier.pmid1676024en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29597/1/0000686.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2889(91)90094-Hen_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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