Recovery and purification of no-carrier-added [18F]fluoride with bistrimethylsilylsulfate (BTMSS)
dc.contributor.author | Mulholland, G. Keith | en_US |
dc.date.accessioned | 2006-04-10T14:56:16Z | |
dc.date.available | 2006-04-10T14:56:16Z | |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Mulholland, G. Keith (1991)."Recovery and purification of no-carrier-added [18F]fluoride with bistrimethylsilylsulfate (BTMSS)." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 42(11): 1003-1008. <http://hdl.handle.net/2027.42/29654> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6X3S-46Y3GVC-DX/2/ec4bba9d2273c8faa7aec335959897a5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29654 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1667308&dopt=citation | en_US |
dc.description.abstract | No-carrier-added trimethylsilyl[18F]fluoride (TMS[18F]F) was rapidly liberated from a variety of dry supports containing unreactive [18F]fluoride by simply heating with neat bistrimethylsilylsulfate. The supports included calcium phosphate, anion exchange resins, alumina, borosilicate and porous carbon beads, to which [18F]fluoride was applied by absorption or evaporation of aqueous solution. TMS[18F]F was evolved essentially free of entrained moisture or excess silylating agent and was efficiently absorbed and rapidly cleaved to free [18F]fluoride ion by 0.1% benzyltrimethylammonium methoxide in anhydrous methanol. Passage of this solution through a strong cation exchange column provided purified hydrogen[18F]fluoride, which was subsequently trapped on a quaternary 4-aminopyridinium resin and used for heterogeneous nucleophilic radiofluorination of 1,3,4,6-tetraacetyl-beta-mannopyranose-2-triflate in 70% yield. The purified [18F]fluoride was also used for solution phase nucleophilic labeling of ethyl [18F]4-fluorobenzoate following addition of K2CO3/Kryptofix and DMSO. This approach provides a simplified way to ensure high reactivity in [18F]fluoride ion from cyclotron targets. It also may be used to salvage active [18F]fluoride ion from insoluble complexes and radiofluorination reaction residues. | en_US |
dc.format.extent | 683737 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Recovery and purification of no-carrier-added [18F]fluoride with bistrimethylsilylsulfate (BTMSS) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.identifier.pmid | 1667308 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29654/1/0000743.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2889(91)90001-H | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.