Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion
dc.contributor.author | Jatlow, P. | en_US |
dc.contributor.author | Elsworth, J. D. | en_US |
dc.contributor.author | Bradberry, C. W. | en_US |
dc.contributor.author | Winger, Gail D. | en_US |
dc.contributor.author | Taylor, J. R. | en_US |
dc.contributor.author | Russell, R. | en_US |
dc.contributor.author | Roth, R. H. | en_US |
dc.date.accessioned | 2006-04-10T14:57:03Z | |
dc.date.available | 2006-04-10T14:57:03Z | |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Jatlow, P., Elsworth, J. D., Bradberry, C. W., Winger, G., Taylor, J. R., Russell, R., Roth, R. H. (1991)."Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion." Life Sciences 48(18): 1787-1794. <http://hdl.handle.net/2027.42/29671> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T99-475497H-NX/2/316a67e2fb2798cbefc8b57e236d63c6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29671 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2020260&dopt=citation | en_US |
dc.description.abstract | High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on the dopamine uptake system and its behavioral effects with those of cocaine. EC was equipotent to cocaine with respect to inhibition of binding of [3H]GBR 12395 to the dopamine reuptake complex, inhibition of [3H]dopamine uptake into synaptosomes and in its ability to increase extracellular dopamine concentration in the nucleus accumbens following its systemic administration to rats. Moreover, in rats, EC and cocaine each increased locomotor activity and rearing to the same extent following i.p. administration. In self-administration studies in primates, EC was approximately equipotent to cocaine in maintaining responding. The in vivo formation of this active, transesterified ethyl homolog of cocaine may contribute to the effects and consequences of combined cocaine and ethanol abuse. | en_US |
dc.format.extent | 538691 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Cocaethylene: A neuropharmacologically active metabolite assciated with concurrent cocaine-ethanol ingestion | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA; Department of Laboratory of Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA. | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA | en_US |
dc.contributor.affiliationother | Department of Laboratory of Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510, USA. | en_US |
dc.identifier.pmid | 2020260 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29671/1/0000760.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0024-3205(91)90217-Y | en_US |
dc.identifier.source | Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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