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Chronic ethanol consumption depresses hypothalamic-pituitary-adrenal function in aged rats

dc.contributor.authorNolan, Colleen J.en_US
dc.contributor.authorBestervelt, Lorelle L.en_US
dc.contributor.authorMousigian, Carol A.en_US
dc.contributor.authorMaimansomsuk, Phaitoonen_US
dc.contributor.authorCai, Yongen_US
dc.contributor.authorPiper, Walter N.en_US
dc.date.accessioned2006-04-10T14:57:08Z
dc.date.available2006-04-10T14:57:08Z
dc.date.issued1991en_US
dc.identifier.citationNolan, Colleen J., Bestervelt, Lorelle L., Mousigian, Carol A., Maimansomsuk, Phaitoon, Cai, Yong, Piper, Walter N. (1991)."Chronic ethanol consumption depresses hypothalamic-pituitary-adrenal function in aged rats." Life Sciences 49(25): 1923-1928. <http://hdl.handle.net/2027.42/29673>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-47549PK-WC/2/1753cabe62b99f185c4aed83621bde4den_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29673
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1660558&dopt=citationen_US
dc.description.abstractIn separate experiments, nine (n=20) and fifteen (n=12) month old rats were treated with either 6% ethanol or 12% sucrose (to balance caloric intake) in the drinking water to examine the effect of chronic ethanol consumption on the hypothalamic-pituitary-adrenal axis of aged rats. Rats were maintained on these treatment regimens for thirty days and were killed by decapitation. Blood was collected and plasma concentrations of adrenocorticotropin (ACTH) and corticosterone were determined by radioimmunoassay. Adrenal glands were cleaned, quartered and used to test in vitro responsiveness to ACTH. Anterior pituitary glands from all 15 month old rats and one half of the nine month old rats were collected, frozen and extracted for measurement of tissue ACTH concentration. The remaining anterior pituitary glands from the nine month old rats were challenged with corticotropin releasing hormone (CRH) to test in vitro responsiveness. In nine month old rats, chronic ethanol consumption decreased plasma ACTH and corticosterone (P In vitro responsiveness of the adrenal gland to ACTH in nine month old rats consuming ethanol was unchanged (P &gt; 0.05). Plasma ACTH and corticosterone concentrations were also decreased in 15 month old rats chronically consuming ethanol (P 0.05). The results of these experiments indicate that chronic ethanol consumption decreases hypothalamic-pituitary-adrenal function in aged rats.en_US
dc.format.extent351524 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleChronic ethanol consumption depresses hypothalamic-pituitary-adrenal function in aged ratsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, USAen_US
dc.contributor.affiliationumToxicology Program, School of Public Health, Department of Pharmacology, Medical School and Reproductive Sciences Program, The University of Michigan, USAen_US
dc.identifier.pmid1660558en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29673/1/0000762.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(91)90294-Len_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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