Creation of immunoglobulin diversity by intrachromosomal gene conversion
dc.contributor.author | Thompson, Craig B. | en_US |
dc.date.accessioned | 2006-04-10T14:58:47Z | |
dc.date.available | 2006-04-10T14:58:47Z | |
dc.date.issued | 1992-12 | en_US |
dc.identifier.citation | Thompson, Craig B. (1992/12)."Creation of immunoglobulin diversity by intrachromosomal gene conversion." Trends in Genetics 8(12): 416-422. <http://hdl.handle.net/2027.42/29702> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TCY-48NJVBV-5/2/7b5c86ecc9c49cda9d9548b49a54d851 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29702 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1492367&dopt=citation | en_US |
dc.description.abstract | Not all vertebrates create an immunoglobulin repertoire through the recombination of individual members of variable (V), diversity (D) and joining (J) gene segment families. In chickens, for example, a diverse set of immunoglobulins is created by intrachromosomal gene conversion of the single variable gene segments of the immunoglobulin heavy and light chain genes. Recent evidence from other species such as the rabbit suggests that gene conversion may be a more widespread mechanism for the creation of immunologic diversity than previously supposed. | en_US |
dc.format.extent | 804547 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Creation of immunoglobulin diversity by intrachromosomal gene conversion | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and Departments of Internal Medicine and Microbiology/Immunology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 1492367 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29702/1/0000034.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0168-9525(92)90324-W | en_US |
dc.identifier.source | Trends in Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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