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Residual effects of tracer in sequential double label deoxyglucose studies
dc.contributor.authorLyon, M. J.en_US
dc.contributor.authorAgranoff, Bernard W.en_US
dc.contributor.authorSokoloff, L.en_US
dc.contributor.authorSmith, C. Beebeen_US
dc.date.accessioned2006-04-10T14:59:36Z
dc.date.available2006-04-10T14:59:36Z
dc.date.issued1992-11-23en_US
dc.identifier.citationLyon, M. J., Agranoff, B. W., Sokoloff, L., Smith, C. Beebe (1992/11/23)."Residual effects of tracer in sequential double label deoxyglucose studies." Neuroscience Letters 147(1): 72-76. <http://hdl.handle.net/2027.42/29722>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485RH40-72/2/4ae72ac3ec617ff5a931bef84bd381acen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29722
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1480326&dopt=citationen_US
dc.description.abstractThe validity of sequential double label deoxyglucose (DG) determinations of local metabolic rate for glucose (IMRglc) was examined by quantifying the degree of trapping of residual first DG tracer during the second experimental period. One sciatic nerve was repetitively stimulated for 25 min, beginning either at the time of the DG injection or 25 min later. IMRglc in the ipsilateral dorsal horn of the lumbar spinal cord was found to be 105% and 56%, respectively, greater than that of the contralateral unstimulated side. Attempts to lower the body burden of radioactive DG by exchange blood transfusion failed to reduce this delayed effect. These data indicate that residual effects of the first tracer could obscure possible differences in IMRglc between two sequential experimental states.en_US
dc.format.extent460008 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleResidual effects of tracer in sequential double label deoxyglucose studiesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Laboratory, Mental Health Research Institute, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Otolaryngology, State University of New York Health Science Center, Syracuse, NY, USAen_US
dc.contributor.affiliationotherLaboratory of Cerebral Metabolism, National Institute of Mental Health, U.S. Public Health Service, Department of Health and Human Services, Bethesda, MD, USAen_US
dc.contributor.affiliationotherLaboratory of Cerebral Metabolism, National Institute of Mental Health, U.S. Public Health Service, Department of Health and Human Services, Bethesda, MD, USAen_US
dc.identifier.pmid1480326en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29722/1/0000056.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(92)90777-5en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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