Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis
dc.contributor.author | Rosenschein, Uri | en_US |
dc.contributor.author | Yakubov, Steven J. | en_US |
dc.contributor.author | Guberinich, Dejan | en_US |
dc.contributor.author | Bach, David S. | en_US |
dc.contributor.author | Sonda, Paul L. | en_US |
dc.contributor.author | Abrams, Gerald D. | en_US |
dc.contributor.author | Topol, Eric J. | en_US |
dc.date.accessioned | 2006-04-10T14:59:50Z | |
dc.date.available | 2006-04-10T14:59:50Z | |
dc.date.issued | 1992-11-15 | en_US |
dc.identifier.citation | Rosenschein, Uri, Yakubov, Steven J., Guberinich, Dejan, Bach, David S., Sonda, Paul L., Abrams, Gerald D., Topol, Eric J. (1992/11/15)."Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis." The American Journal of Cardiology 70(15): 1358-1361. <http://hdl.handle.net/2027.42/29728> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T10-4CC7MW6-6R/2/2a86bdfdae1d336a786fafe971030b1e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29728 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1442591&dopt=citation | en_US |
dc.description.abstract | Successful experimental and clinical experience with thrombus ablation has been attained with high-power acoustic energy delivered in a catheter. The goal of this study was to investigate the feasibility of noninvasive thrombus ablation by focused high-power acoustic energy. The source for high-power acoustic energy was a shock-wave generator in a water tank equipped with an acoustic lens with a fixed focal point at 22.5 cm. Thrombus was prepared in vitro, weighed (0.24 +/- 0.08 g), and inserted in excised human femoral artery segments. The arterial segments were ligated, positioned at the focal point and then randomized into either test (n = 8) or control (n = 7). An x-ray system verified the 3-dimensional positioning of the arterial segment at the focal point. A 5 MHz ultrasound imaging system continuously visualized the arterial segment at the focal point before, during and after each experiment. The test segments were exposed to shock waves (1,000 shocks/24 kv). The arterial segment content was then flushed and the residual thrombus weighed. The arterial segment and thrombus were fixed and submitted to histologic examination. The test group achieved a significant ablation of thrombus mass (0.25 +/- 0.15 vs 0.07 +/- 0.003 g; P = 0.0001) after application of shock waves. Arterial segments showed no gross or microscopic damage. Ultrasound imaging revealed a localized (1.9 +/- 0.5 cm2), transient (744 +/- 733 ms), cavitation field at the focal point at the time of application of focused shock waves. Thus, focused high-power acoustic energy can effect noninvasive thrombus ablation without apparent damage to the arterial wall. The mechanism underlying shock-wave thrombus ablation may be associated with the cavitation effect. | en_US |
dc.format.extent | 2079170 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Shock-wave thrombus ablation, a new method for noninvasive mechanical thrombolysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA. | en_US |
dc.contributor.affiliationum | Departments of Urology and Pathology, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA; Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. | en_US |
dc.identifier.pmid | 1442591 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29728/1/0000064.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9149(92)90775-T | en_US |
dc.identifier.source | The American Journal of Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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