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Rapid communication : Inhibition of adenosine deaminase by azapurine ribonucleosides
dc.contributor.authorShewach, Donna S.en_US
dc.contributor.authorKrawczyk, Steven H.en_US
dc.contributor.authorAcevedo, Oscar L.en_US
dc.contributor.authorTownsend, Leroy B.en_US
dc.date.accessioned2006-04-10T15:00:00Z
dc.date.available2006-04-10T15:00:00Z
dc.date.issued1992-11-03en_US
dc.identifier.citationShewach, Donna S., Krawczyk, Steven H., Acevedo, Oscar L., Townsend, Leroy B. (1992/11/03)."Rapid communication : Inhibition of adenosine deaminase by azapurine ribonucleosides." Biochemical Pharmacology 44(9): 1697-1700. <http://hdl.handle.net/2027.42/29732>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4P-4779565-29/2/1a8983d6d20e7c95f55a4214141349afen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29732
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1449528&dopt=citationen_US
dc.description.abstractWe have synthesized several 8-azapurine nucleosides as inhibitors of adenosine deaminase. The presence of a nitrogen on the imidazole ring decreased the Ki value for nebularine by 100-fold but did not lower the Ki value for coformycin. Evaluation of these compounds in a MOLT-4 growth assay revealed that 2-azacoformycin was as effective as 2'-deoxycoformycin in potentiating growth inhibition by 2'-deoxyadenosine. The azapurine nucleosides merit further study as antitumor agents.en_US
dc.format.extent473509 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleRapid communication : Inhibition of adenosine deaminase by azapurine ribonucleosidesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid1449528en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29732/1/0000068.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-2952(92)90061-Men_US
dc.identifier.sourceBiochemical Pharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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