[beta]-Endorphin processing and cellular origins in rat spinal cord
dc.contributor.author | Gutstein, Howard B. | en_US |
dc.contributor.author | Bronstein, David M. | en_US |
dc.contributor.author | Akil, Huda | en_US |
dc.date.accessioned | 2006-04-10T15:00:47Z | |
dc.date.available | 2006-04-10T15:00:47Z | |
dc.date.issued | 1992-11 | en_US |
dc.identifier.citation | Gutstein, Howard B., Bronstein, David M., Akil, Huda (1992/11)."[beta]-Endorphin processing and cellular origins in rat spinal cord." Pain 51(2): 241-247. <http://hdl.handle.net/2027.42/29750> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0K-487D1VV-NF/2/e017b49074d9c41b742ada52f5636056 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29750 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1336592&dopt=citation | en_US |
dc.description.abstract | While enkephalin and dynorphin peptides have been well characterized in the spinal cord, the cellular localization of [beta]-endorphin ([beta]E) and the processing of pro-opiomelanocortin (POMC) to [beta]E and other non-opioid peptides in the cord have not been extensively investigated. Other investigators have characterized the various [beta]E forms present in rat spinal cord regions. Previous studies have also suggested that spinal POMC content is entirely derived from supraspinal sources. However, high proportions of [beta]E precursors present in spinal cord sieving profiles led us to suspect the presence of POMC cell bodies intrinsic to the cord. In this study, we performed thoracic spinal cord lesions on a group of animals and demonstrated the persistence of about one-third of control levels of [beta]E immunoreactivity ([beta]E-IR) below the level of the lesions. We also characterized POMC processing in various regions of the spinal cord both before and after lesioning. These data suggested that there may be intrinsic POMC/endorphinergic neuronal systems in the spinal cord. | en_US |
dc.format.extent | 885827 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [beta]-Endorphin processing and cellular origins in rat spinal cord | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anesthesiology and Mental Health Research Institute, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Anesthesiology and Mental Health Research Institute, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Anesthesiology and Mental Health Research Institute, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 1336592 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29750/1/0000088.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3959(92)90265-D | en_US |
dc.identifier.source | Pain | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.