Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia
dc.contributor.author | Werns, Steven W. | en_US |
dc.contributor.author | Fantone, Joseph C. | en_US |
dc.contributor.author | Ventura, Anthony | en_US |
dc.contributor.author | Lucchesi, Benedict Robert | en_US |
dc.date.accessioned | 2006-04-10T15:01:52Z | |
dc.date.available | 2006-04-10T15:01:52Z | |
dc.date.issued | 1992-11 | en_US |
dc.identifier.citation | Werns, Steven W., Fantone, Joseph C., Ventura, Anthony, Lucchesi, Benedict R. (1992/11)."Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia." Journal of Molecular and Cellular Cardiology 24(11): 1215-1220. <http://hdl.handle.net/2027.42/29775> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WK6-4C52H0M-P0/2/d55ac8371d32c8cc96a1afa77379fdef | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29775 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1362226&dopt=citation | en_US |
dc.description.abstract | This study was performed to determine whether depletion of myocardial glutathione would impair recovery of left ventricular function of blood-perfused, isolated hearts after reversible ischaemic injury. Cats were treated with either vehicle or buthionine sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the synthesis of glutathione. The feline isolated hearts were perfused with the blood of normal donor cats before and after 40 min of global myocardial ischaemia. The myocardial concentration of glutathione of the BSO group, 178+/-38 ng/mg tissue, was significantly less than that of the control group, 292+/-38 ng/mg tissue (PP=0.05 vs. control). The peak left ventricular dP/dt after reperfusion, expressed as a fraction of the peak dP/dt before ischaemia, was 1.08+/-0.14 for the control group and 0.78+/-0.09 for the BSO group (P=0.05 vs. control). The myocardial creatine kinase activity of the BSO group, 1046+/-46 U/g tissue, was not significantly different from that of the control group, 1038+/-17 U/g tissue (P=0.87). Thus, depletion of myocardial glutathione resulted in impaired post-ischaemic contractile function that cannot be attributed to a greater extent of irreversible cell injury. | en_US |
dc.format.extent | 582813 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Cardiology), The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Cardiology), The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Cardiology), The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Internal Medicine (Division of Cardiology), The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | en_US |
dc.identifier.pmid | 1362226 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29775/1/0000114.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-2828(92)93088-2 | en_US |
dc.identifier.source | Journal of Molecular and Cellular Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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