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The microsomal calcium-ATPase inhibitor thapsigargin is a neurotoxin in perinatal rodent brain

dc.contributor.authorSilverstein, Faye Sarahen_US
dc.contributor.authorNelson, Carrieen_US
dc.date.accessioned2006-04-10T15:02:26Z
dc.date.available2006-04-10T15:02:26Z
dc.date.issued1992-10-12en_US
dc.identifier.citationSilverstein, Faye S., Nelson, Carrie (1992/10/12)."The microsomal calcium-ATPase inhibitor thapsigargin is a neurotoxin in perinatal rodent brain." Neuroscience Letters 145(2): 157-160. <http://hdl.handle.net/2027.42/29789>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-485H68R-K3/2/06026bb862ef71c83b3a866494c85429en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29789
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1465212&dopt=citationen_US
dc.description.abstractThapsigargin is a potent inhibitor of the microsomal calcium-ATPase. We hypothesized that thapsigargin-induced liberation of calcium from sequestered intracellular sites could result in irreversible brain injury. To assess neurotoxicity, intracerebral injections of 0.1-100 nmol thapsigargin were performed in 7-day-old rats, and the severity of injury was assessed 5 days later by microscopy and measurements of lesioned areas. We found that thapsigargin elicited dose-dependent tissue injury in perinatal rodent brain.en_US
dc.format.extent387451 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe microsomal calcium-ATPase inhibitor thapsigargin is a neurotoxin in perinatal rodent brainen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid1465212en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29789/1/0000131.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(92)90010-5en_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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