Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages
dc.contributor.author | Koch, Alisa E. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.contributor.author | Haines, G. Kenneth III | en_US |
dc.contributor.author | Strieter, Robert M. | en_US |
dc.date.accessioned | 2006-04-10T15:02:48Z | |
dc.date.available | 2006-04-10T15:02:48Z | |
dc.date.issued | 1992-10 | en_US |
dc.identifier.citation | Koch, Alisa E., Kunkel, Steven L., Chensue, Steven W., Haines, G. Kenneth, Strieter, Robert M. (1992/10)."Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages." Clinical Immunology and Immunopathology 65(1): 23-29. <http://hdl.handle.net/2027.42/29796> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WCK-4CC97YW-2M/2/be94633975fa4d7beabb34d4a916b1b4 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29796 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1395121&dopt=citation | en_US |
dc.description.abstract | Interleukin-1 (IL-1) has protean effects in the pathogenesis of rheumatoid arthritis (RA). These effects include production of prostaglandins and collagenase from rheumatoid fibroblasts as well as upregulation of adhesion molecule expression on these cells. IL-1 can activate monocytes and neutrophils, as well as promote the growth of fibroblasts and endothelial cells. Recently, a novel interleukin-1 receptor antagonist protein (IRAP) has been isolated, purified, cloned, and expressed, which may modulate the effects of IL-1. In this study, we present data demonstrating that macrophages isolated from human RA synovial tissues express both IL-1 and IRAP genes. In addition, RA synovial tissue macrophages and lining cells display IL-1 and IRAP antigenic expression by immunohistochemistry. In contrast, osteoarthritis synovial tissues, as compared to RA, have fewer IL-1 and IRAP-positive macrophages. Thus, the production of IL-1 balanced by IRAP may affect the joint destruction found in these diseases. | en_US |
dc.format.extent | 1371379 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Veteran's Administration Lakeside, Chicago, Illinois 60611, USA. | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Veteran's Administration Lakeside, Chicago, Illinois 60611, USA. | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; Department of Medicine, Northwesern University, Chicago, Illinois 60611, USA. | en_US |
dc.contributor.affiliationother | Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA; Department of Medicine, Northwesern University, Chicago, Illinois 60611, USA. | en_US |
dc.contributor.affiliationother | Veteran's Affairs Medical Center, Ann Arbor, Michigan 48109, USA; Veteran's Administration Lakeside, Chicago, Illinois 60611, USA. | en_US |
dc.identifier.pmid | 1395121 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29796/1/0000142.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0090-1229(92)90243-H | en_US |
dc.identifier.source | Clinical Immunology and Immunopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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