Localization of the gene encoding R[kappa]B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25
dc.contributor.author | Adams, Barbara S. | en_US |
dc.contributor.author | Leung, Kwanyee | en_US |
dc.contributor.author | Meltzer, Paul S. | en_US |
dc.contributor.author | Lewis, Kathy A. | en_US |
dc.contributor.author | Wagner-Mc Pherson, Caryn | en_US |
dc.contributor.author | Evans, Glen A. | en_US |
dc.contributor.author | Nabel, Gary J. | en_US |
dc.date.accessioned | 2006-04-10T15:03:27Z | |
dc.date.available | 2006-04-10T15:03:27Z | |
dc.date.issued | 1992-10 | en_US |
dc.identifier.citation | Adams, Barbara S., Leung, Kwanyee, Meltzer, Paul S., Lewis, Kathy A., Wagner-McPherson, Caryn, Evans, Glen A., Nabel, Gary J. (1992/10)."Localization of the gene encoding R[kappa]B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25." Genomics 14(2): 270-274. <http://hdl.handle.net/2027.42/29810> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4GPWSN3-9/2/c520659ccc8e979c3c28339dfb7b3ec8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29810 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1427843&dopt=citation | en_US |
dc.description.abstract | Although NF (nuclear factor)-[kappa]B binds in vitro to several of the [kappa]B regulatory elements found in cellular and viral genes, another DNA binding protein, R[kappa]B, also binds to a related variant of the [kappa]B site that regulates interleukin-2 receptor [alpha]-chain gene expression, a critical event in T cell activation. Southern blot analysis of a human-mouse somatic cell hybrid panel and in situ hybridization using a fluorescent genomic R[kappa]B probe have allowed assignment of the R[kappa]B gene (NFRKB) to 11q24-q25. The NFRKB locus is in close proximity to the chromosomal breakpoint implicated in Ewing sarcoma, but it does not appear to span this region. Nonetheless, NFRKB may be particularly useful as the most telomeric marker thus far assigned to 11q. | en_US |
dc.format.extent | 598382 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Localization of the gene encoding R[kappa]B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USA | en_US |
dc.contributor.affiliationother | Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, USA | en_US |
dc.contributor.affiliationother | Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, USA | en_US |
dc.contributor.affiliationother | Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA | en_US |
dc.contributor.affiliationother | Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA | en_US |
dc.contributor.affiliationother | Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA | en_US |
dc.contributor.affiliationother | Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, USA | en_US |
dc.identifier.pmid | 1427843 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29810/1/0000156.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0888-7543(05)80216-2 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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