An altered repertoire of fos/jun (AP-1) at the onset of replicative senescence
dc.contributor.author | Irving, John | en_US |
dc.contributor.author | Feng, Junli | en_US |
dc.contributor.author | Wistrom, Cheryl | en_US |
dc.contributor.author | Pikaart, Michael | en_US |
dc.contributor.author | Villeponteau, Bryant | en_US |
dc.date.accessioned | 2006-04-10T15:05:38Z | |
dc.date.available | 2006-04-10T15:05:38Z | |
dc.date.issued | 1992-09 | en_US |
dc.identifier.citation | Irving, John, Feng, Junli, Wistrom, Cheryl, Pikaart, Michael, Villeponteau, Bryant (1992/09)."An altered repertoire of fos/jun (AP-1) at the onset of replicative senescence." Experimental Cell Research 202(1): 161-166. <http://hdl.handle.net/2027.42/29861> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WFC-4DM22WF-36/2/ee903555f26c1d88c5d358fb5256752b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29861 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1511730&dopt=citation | en_US |
dc.description.abstract | With multiple divisions in culture, normal diploid cells suffer a loss of growth potential that leads to replicative senescence and a finite replicative capacity. Using quantitative RT-PCR, we have monitored mRNA expression levels of c-fos, c-jun, JunB, c-myc, p53, H-ras, and histone H4 during the replicative senescence of human fibroblasts. The earliest and the largest changes in gene expression occurred in c-fosand junB at mid-senescence prior to the first slowing in cell growth rates. The basal level of c-fos mRNA decreased to one-ninth that of the early-passage levels, while junB declined to one-third and c-jun expression remained constant. The decline in the basal c-fos mRNA level in mid-senescence should lead to an increase in Jun/Jun AP-1 homodimers at the expense of Fos/Jun heterodimers and may trigger a cascade of further changes in c-myc, p53, and H-ras expression in late-passage senescent fibroblasts. | en_US |
dc.format.extent | 1585168 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | An altered repertoire of fos/jun (AP-1) at the onset of replicative senescence | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A. | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A. | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A.; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A. | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A.; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A.; Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48105-2007, U.S.A. | en_US |
dc.identifier.pmid | 1511730 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29861/1/0000209.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0014-4827(92)90415-5 | en_US |
dc.identifier.source | Experimental Cell Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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