View Item 

Show simple item record

Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7
dc.contributor.authorJones, Julie M.en_US
dc.contributor.authorMeisler, Miriam H.en_US
dc.contributor.authorSeldin, Michael F.en_US
dc.contributor.authorLee, Barbara K.en_US
dc.contributor.authorEicher, Eva M.en_US
dc.date.accessioned2006-04-10T15:05:46Z
dc.date.available2006-04-10T15:05:46Z
dc.date.issued1992-09en_US
dc.identifier.citationJones, Julie M., Meisler, Miriam H., Seldin, Michael F., Lee, Barbara K., Eicher, Eva M. (1992/09)."Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7." Genomics 14(1): 197-199. <http://hdl.handle.net/2027.42/29864>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4GY9704-18/2/ef0e2d354e0c891d6c1a59b66cd92b45en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29864
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1358794&dopt=citationen_US
dc.description.abstractA DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse conserved linkage group that includes Th, H19, and Igf-2. Analysis of segregation in the F2 generation from the cross C57BL/6J-tub/tub x CAST/Ei demonstrated that Ins-2 and the obesity mutant tubby (tub) are distinct loci, thus eliminating Ins-2 as a candidate gene for tub. These results also refine the estimated genetic distance between tub and Hbb to 2.4 [plus-or-minus sign] 1.4 cM. The predicted location for a human homolog of tubby is HSA 11p15.en_US
dc.format.extent598678 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleLocalization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618, USAen_US
dc.contributor.affiliationotherDepartments of Medicine and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USAen_US
dc.contributor.affiliationotherThe Jackson Laboratory, Bar Harbor, Maine 04609, USAen_US
dc.contributor.affiliationotherThe Jackson Laboratory, Bar Harbor, Maine 04609, USAen_US
dc.identifier.pmid1358794en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29864/1/0000212.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0888-7543(05)80308-8en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000212.pdf
Size:
584.6KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.