Ibuprofen intervention in canine septic shock: Reduction of pathophysiology without decreased cytokines
dc.contributor.author | Coran, Arnold G. | en_US |
dc.contributor.author | Drongowski, Robert A. | en_US |
dc.contributor.author | Paik, Jane J. | en_US |
dc.contributor.author | Remick, Daniel G. | en_US |
dc.date.accessioned | 2006-04-10T15:05:58Z | |
dc.date.available | 2006-04-10T15:05:58Z | |
dc.date.issued | 1992-09 | en_US |
dc.identifier.citation | Coran, Arnold G., Drongowski, Robert A., Paik, Jane J., Remick, Daniel G. (1992/09)."Ibuprofen intervention in canine septic shock: Reduction of pathophysiology without decreased cytokines." Journal of Surgical Research 53(3): 272-279. <http://hdl.handle.net/2027.42/29869> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNDX09-G8/2/9bc29e5a9c3deff7b24380335a258f20 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29869 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1326683&dopt=citation | en_US |
dc.description.abstract | This study was undertaken to evaluate the effect of a cyclooxygenase inhibitor, ibuprofen, at various time intervals in a live Escherichia coli model of canine septic shock. Group I (control) animals (n = 5) received a LD100 dose of 109 live E. coli per kilogram were given no further treatment. Group II animals (n = 5) received a 10 mg/kg bolus of ibuprofen 10 min prior to bacterial infusion. Group III animals (n = 5) received ibuprofen 15 min after the bacterial infusion. Statistical analysis revealed the following: Group II animals had significantly higher MABP and significantly lower levels of serum fluorescent products (superoxide radical activity), plasma thromboxane B2, prostaglandin E2, and endotoxin levels compared to Group I animals (P P E. coli septic shock without depressing the endogenous production of TNF or IL-6. These data support the hypothesis that sepsis initiates a cascade of mediators with the cytokines TNF and IL-6 being proximal events which in turn stimulate the next level, with ibuprofen probably exerting its inhibitory effect distal to this point in the cascade. | en_US |
dc.format.extent | 881654 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Ibuprofen intervention in canine septic shock: Reduction of pathophysiology without decreased cytokines | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C. S. Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Michigan 48109-0245, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C. S. Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Michigan 48109-0245, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C. S. Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Michigan 48109-0245, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C. S. Mott Children's Hospital and University of Michigan Medical School, Ann Arbor, Michigan 48109-0245, USA | en_US |
dc.identifier.pmid | 1326683 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29869/1/0000218.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(92)90047-4 | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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