PPACK-thrombin is a noncompetitive inhibitor of [alpha]-thrombin binding to human platelets
dc.contributor.author | Schmaier, Alvin H. | en_US |
dc.contributor.author | Meloni, F. J. | en_US |
dc.contributor.author | Nawarawong, W. | en_US |
dc.contributor.author | Jiang, Y. P. | en_US |
dc.date.accessioned | 2006-04-10T15:06:30Z | |
dc.date.available | 2006-04-10T15:06:30Z | |
dc.date.issued | 1992-09-01 | en_US |
dc.identifier.citation | Schmaier, A. H., Meloni, F. J., Nawarawong, W., Jiang, Y. P. (1992/09/01)."PPACK-thrombin is a noncompetitive inhibitor of [alpha]-thrombin binding to human platelets." Thrombosis Research 67(5): 479-489. <http://hdl.handle.net/2027.42/29882> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1C-4C06B48-6V/2/4efbff8041ba0e6d41e52a32a85c8c60 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29882 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1448784&dopt=citation | en_US |
dc.description.abstract | Recent studies from our laboratory indicate that purified kininogens are noncompetitive inhibitors of human [alpha]-thrombin but not PPACK-thrombin, binding to human washed platelets. In order to understand the mechanism by which the kininogens inhibit [alpha]-thrombin binding, investigations were initiated to determine if [alpha]-thrombin and PPACK-thrombin bound to the same site on human platelets. Initial investigations reveal that [alpha]-thrombin is a more potent inhibitor of 125I-PPACK-thrombin binding than PPACK-thrombin. Further studies show that PPACK-thrombin is a noncompetitive inhibitor of 125I-[alpha]-thrombin binding to platelets. These studies suggest that human [alpha]-thrombin binds on the platelet surface to a different site or binds differently to the same site from PPACK-thrombin. These data indicate that the ability of the kininogens to block [alpha]-thrombin binding to platelets but not PPACK-thrombin binding results from these thrombins having either two different binding sites or one binding site on the platelet surface which they interact with differently. | en_US |
dc.format.extent | 757063 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | PPACK-thrombin is a noncompetitive inhibitor of [alpha]-thrombin binding to human platelets | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Thomas Jefferson University, Philadelphia PA 19107, USA | en_US |
dc.contributor.affiliationother | Temple University School of Medicine, Philadelphia, PA 19140, USA | en_US |
dc.identifier.pmid | 1448784 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29882/1/0000235.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0049-3848(92)90010-8 | en_US |
dc.identifier.source | Thrombosis Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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