Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent
dc.contributor.author | Schwendner, Susan W. | en_US |
dc.contributor.author | Weichert, Jamey P. | en_US |
dc.contributor.author | Longino, Marc A. | en_US |
dc.contributor.author | Gross, Milton D. | en_US |
dc.contributor.author | Counsell, Raymond E. | en_US |
dc.date.accessioned | 2006-04-10T15:08:31Z | |
dc.date.available | 2006-04-10T15:08:31Z | |
dc.date.issued | 1992-08 | en_US |
dc.identifier.citation | Schwendner, S. W., Weichert, J. P., Longino, M. A., Gross, M. D., Counsell, R. E. (1992/08)."Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 19(6): 639-647. <http://hdl.handle.net/2027.42/29932> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B7GH9-4C00NH8-5X/2/6afc5fadf62624336fe37c8206dfaece | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29932 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1522018&dopt=citation | en_US |
dc.description.abstract | A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by [gamma] -camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent. | en_US |
dc.format.extent | 1461287 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pharmacology, M6322 Medical Science I, University of Michigan Medical School, Ann Arbor, MI 48109-0626, U.S.A. | en_US |
dc.contributor.affiliationother | Nuclear Medicine Unit, VA Medical Center, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.identifier.pmid | 1522018 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29932/1/0000289.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2897(92)90098-J | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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