Identification of new markers in Xp21 between DXS28 (C7) and DMD
dc.contributor.author | Worley, K. C. | en_US |
dc.contributor.author | Towbin, Jeffrey A. | en_US |
dc.contributor.author | Zhu, X. M. | en_US |
dc.contributor.author | Barker, D. F. | en_US |
dc.contributor.author | Ballabio, Andrea | en_US |
dc.contributor.author | Chamberlain, Jeffrey S. | en_US |
dc.contributor.author | Biesecker, Leslie G. | en_US |
dc.contributor.author | Blethen, S. L. | en_US |
dc.contributor.author | Brosnan, P. | en_US |
dc.contributor.author | Fox, J. E. | en_US |
dc.date.accessioned | 2006-04-10T15:08:38Z | |
dc.date.available | 2006-04-10T15:08:38Z | |
dc.date.issued | 1992-08 | en_US |
dc.identifier.citation | Worley, K. C., Towbin, J. A., Zhu, X. M., Barker, D. F., Ballabio, A., Chamberlain, J., Biesecker, L. G., Blethen, S. L., Brosnan, P., Fox, J. E. (1992/08)."Identification of new markers in Xp21 between DXS28 (C7) and DMD." Genomics 13(4): 957-961. <http://hdl.handle.net/2027.42/29935> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DNHP53-35/2/1d8215267252b7ec16b0b040b1886182 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29935 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1505987&dopt=citation | en_US |
dc.description.abstract | Characterization of Xp21 distal to Duchenne muscular dystrophy (DMD) in the region containing the genes for adrenal hypoplasia congenita (AHC) and glycerol kinase deficiency (GKD) has been limited due to a paucity of probes. Two probes were localized between DXS28 (C7) and AHC, the yeast artificial chromosome insert YHX39 (DXS727) and the polymorphic phage clone QST59 (DXS319). A genomic clone, FT1 (DXS726), 3' to DMD, was also characterized. Portions of the three probes were sequenced and primer pairs were generated to amplify a sequence-tagged site within each probe. Amplification of DNA from patients confirmed the deletion results obtained by Southern blot analysis, and these three sequence-tagged sites were successfully combined for triplex PCR. In addition to facilitating molecular genetic diagnosis in Xp21, these probes can be used to identify additional YACs and other probes to further increase the genomic information and diagnostic capabilities in this region. | en_US |
dc.format.extent | 1378006 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Identification of new markers in Xp21 between DXS28 (C7) and DMD | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Division of Pediatric Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA | en_US |
dc.contributor.affiliationother | Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA | en_US |
dc.contributor.affiliationother | Genetic Epidemiology, University of Utah, Salt Lake City, Utah 84108, USA | en_US |
dc.contributor.affiliationother | Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA | en_US |
dc.contributor.affiliationother | no department found | en_US |
dc.contributor.affiliationother | Driscol Foundation Children's Hospital, Corpus Christi, Texas 78466, USA | en_US |
dc.contributor.affiliationother | Schneider Children's Hospital, New Hyde Park, New York 11042, USA | en_US |
dc.identifier.pmid | 1505987 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29935/1/0000292.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(92)90007-F | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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