Endocrine, cardiovascular, and behavioral responses to clonidine in patients with panic disorder
dc.contributor.author | Abelson, James L. | en_US |
dc.contributor.author | Glitz, Debra | en_US |
dc.contributor.author | Cameron, Oliver G. | en_US |
dc.contributor.author | Lee, Myung Ae | en_US |
dc.contributor.author | Bronzo, Michael R. | en_US |
dc.contributor.author | Curtis, George C. | en_US |
dc.date.accessioned | 2006-04-10T15:09:23Z | |
dc.date.available | 2006-04-10T15:09:23Z | |
dc.date.issued | 1992-07-01 | en_US |
dc.identifier.citation | Abelson, James L., Glitz, Debra, Cameron, Oliver G., Lee, Myung A., Bronzo, Michael, Curtis, George C. (1992/07/01)."Endocrine, cardiovascular, and behavioral responses to clonidine in patients with panic disorder." Biological Psychiatry 32(1): 18-25. <http://hdl.handle.net/2027.42/29953> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4S-484N7CK-K4/2/d11cff30a801b0cb2f91b13ded3b257b | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29953 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1391293&dopt=citation | en_US |
dc.description.abstract | We examines adrenergic regulation in patients with panic disorder by challenging 10 patients and 14 age-matched and sex-matched controls with intravenous infusions of clonidine hydrochloride (2 [mu]g/kg), an alpha2-adrenoreceptor agonist. Growth hormone, 3-methoxy-4-hydroxyphenylglycol (MHPG), blood pressure, heart rate, and behavioral (anxiety, sedation) responses were monitored. The data replicated the previously reported finding of blunted growth hormone (GH) responses to clonidine in patients with panic disorder. Reported abnormalities in MHPG, cardiovascular, and behavioral responses of panic patients to clonidine infusion were not replicated. The robustly blunted GH response to clonidine in panic patients supports the adrenergic dysregulation hypothesis of panic disorder, but alternative interpretations of this finding are available and further study is needed. | en_US |
dc.format.extent | 677737 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Endocrine, cardiovascular, and behavioral responses to clonidine in patients with panic disorder | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Depatment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Depatment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Depatment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Depatment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Depatment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Depatment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 1391293 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29953/1/0000313.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-3223(92)90138-P | en_US |
dc.identifier.source | Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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