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A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene

dc.contributor.authorMarchuk, Douglas A.en_US
dc.contributor.authorTavakkol, Roxanneen_US
dc.contributor.authorWallace, Margaret R.en_US
dc.contributor.authorBrownstein, Bernard H.en_US
dc.contributor.authorTaillon-Miller, Patriciaen_US
dc.contributor.authorFong, Chin-Toen_US
dc.contributor.authorLegius, Ericen_US
dc.contributor.authorAndersen, Lone B.en_US
dc.contributor.authorGlover, Thomas W.en_US
dc.contributor.authorCollins, Francis S.en_US
dc.date.accessioned2006-04-10T15:10:10Z
dc.date.available2006-04-10T15:10:10Z
dc.date.issued1992-07en_US
dc.identifier.citationMarchuk, Douglas A., Tavakkol, Roxanne, Wallace, Margaret R., Brownstein, Bernard H., Taillon-Miller, Patricia, Fong, Chin-To, Legius, Eric, Andersen, Lone B., Glover, Thomas W., Collins, Francis S. (1992/07)."A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene." Genomics 13(3): 672-680. <http://hdl.handle.net/2027.42/29972>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DNHS2F-PH/2/689930a698648482950690532e5a391aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29972
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1639394&dopt=citationen_US
dc.description.abstractThe yeast artificial chromosome (YAC) system (Burke et al., 1987, Science 236: 806-812) allows the direct cloning of large regions of the genome. A YAC contig map of approximately 700 kb encompassing the region surrounding the type 1 neurofibromatosis (NF1) locus on 17q11.2 has been constructed. A single YAC containing the entire NF1 locus has been constructed by homologous recombination in yeast. In the process of contig construction a novel method of YAC end rescue has been developed by YAC circularization in yeast and plasmid rescue in bacteria. YACs containing homology to the NF1 region but mapping to another chromosome have also been discovered. Sequences of portions of the homologous locus indicate that this other locus is a nonprocessed pseudogene.en_US
dc.format.extent3101388 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleA yeast artificial chromosome contig encompassing the type 1 neurofibromatosis geneen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationotherCenter for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63130, USAen_US
dc.contributor.affiliationotherCenter for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63130, USAen_US
dc.contributor.affiliationotherDepartment of Pediatric Genetics, University of Rochester Medical Center, Rochester, New York 14642, USAen_US
dc.identifier.pmid1639394en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29972/1/0000334.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(92)90140-Nen_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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