Reaction rate enhancement by surface diffusion of adsorbates
dc.contributor.author | Wang, Dong | en_US |
dc.contributor.author | Gou, Shi-Yuan | en_US |
dc.contributor.author | Axelrod, Daniel | en_US |
dc.date.accessioned | 2006-04-10T15:11:04Z | |
dc.date.available | 2006-04-10T15:11:04Z | |
dc.date.issued | 1992-06 | en_US |
dc.identifier.citation | Wang, Dong, Gou, Shi-Yuan, Axelrod, Daniel (1992/06)."Reaction rate enhancement by surface diffusion of adsorbates." Biophysical Chemistry 43(2): 117-137. <http://hdl.handle.net/2027.42/29994> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TFB-44FDRGK-S6/2/52983d735f9162996fca8dc3afc582a6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29994 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1498248&dopt=citation | en_US |
dc.description.abstract | Ligands can be captured by a surface target through either direct bulk diffusion or surface diffusion following reversible adsorption to the surface. We have solved a steady state boundary value problem for a perfect sink disk target in the surface, taking into account bulk and surface diffusion coefficients D and Ds and adsorption/desorption kinetic rate constants ka and kd at non-target regions. Solutions have been successfully found by numerical computation. The results show that the rate of capture from the surface depends non-linearly on Ds, D, ka, kd and geometrical dimensions. In particular, we demonstrate that not only is the non-target region equilibrium constant Keq (= ka/kd) important in determining the rate of capture from the surface, but so are the kinetic rate constants ka and kd separately. In all cases, the surface adsorption/diffusion combination enhances the total rate of capture. The results should be useful for predicting reaction rates of biological membrane bound receptor clusters and substrate-immobilized enzymes. | en_US |
dc.format.extent | 1449795 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Reaction rate enhancement by surface diffusion of adsorbates | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.contributor.affiliationum | Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI U.S.A. | en_US |
dc.contributor.affiliationum | Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109 U.S.A.; Department of Physics, University of Michigan, Ann Arbor, MI 48109 U.S.A. | en_US |
dc.identifier.pmid | 1498248 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29994/1/0000361.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0301-4622(92)80027-3 | en_US |
dc.identifier.source | Biophysical Chemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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