[alpha]2-Adrenoceptor modulation of 5-HT biosynthesis in the rat brain
dc.contributor.author | Yoshioka, Mitsuhiro | en_US |
dc.contributor.author | Matsumoto, Machiko | en_US |
dc.contributor.author | Togashi, Hiroko | en_US |
dc.contributor.author | Smith, Charles B. | en_US |
dc.contributor.author | Saito, Hideya | en_US |
dc.date.accessioned | 2006-04-10T15:13:18Z | |
dc.date.available | 2006-04-10T15:13:18Z | |
dc.date.issued | 1992-05-11 | en_US |
dc.identifier.citation | Yoshioka, Mitsuhiro, Matsumoto, Machiko, Togashi, Hiroko, Smith, Charles B., Saito, Hideya (1992/05/11)."[alpha]2-Adrenoceptor modulation of 5-HT biosynthesis in the rat brain." Neuroscience Letters 139(1): 53-56. <http://hdl.handle.net/2027.42/30048> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-482RB54-86/2/999633eafc6ec1a0ebe6c2b091674759 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30048 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1357604&dopt=citation | en_US |
dc.description.abstract | The purpose of the present study is to clarify the modulation of the biosynthesis of serotonin (5-HT) via the [alpha]2-adrenoceptors in the brain. For this purpose. 5-hydroxytryptophan (5-HTP) accumulation was determined using an HPLC-ECD system in the presence of the inhibition of aromatic -amino acid decarboxylase. Administration of [alpha]2-adrenoceptor agonist, clonidine, produced a reduction of the in vivo 5-HTP accumulation in the rat hippocampus and dorsal raphe nucleus. In addition, [alpha]2-adrenoceptor antagonist, idazoxan, increased the 5-HTP accumulation in both the hippocampus and the dorsal raphe nucleus. In rats with catecholaminergic neurons denervated by pretreatment with 6-hydroxydopamine, clonidine failed to produce a reduction of 5-HTP accumulation in the dorsal raphe nucleus. On the other hand, hippocampal 5-HTP accumulation was decreased significantly. Brain tryptophan levels were unaffected by either clonidine or idazoxan. These results suggest that [alpha]2-adrenoceptors might modulate serotonin biosynthesis and this modulation might be related to the neuroanatomical differences in the rat brain. | en_US |
dc.format.extent | 374495 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [alpha]2-Adrenoceptor modulation of 5-HT biosynthesis in the rat brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109-0626, USA | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.identifier.pmid | 1357604 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30048/1/0000416.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(92)90856-3 | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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