Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis
dc.contributor.author | Yoshioka, Mitsuhiro | en_US |
dc.contributor.author | Matsumoto, Machiko | en_US |
dc.contributor.author | Togashi, Hiroko | en_US |
dc.contributor.author | Smith, Charles B. | en_US |
dc.contributor.author | Saito, Hideya | en_US |
dc.date.accessioned | 2006-04-10T15:13:20Z | |
dc.date.available | 2006-04-10T15:13:20Z | |
dc.date.issued | 1992-05-11 | en_US |
dc.identifier.citation | Yoshioka, Mitsuhiro, Matsumoto, Machiko, Togashi, Hiroko, Smith, Charles B., Saito, Hideya (1992/05/11)."Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis." Neuroscience Letters 139(1): 57-60. <http://hdl.handle.net/2027.42/30049> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-482RB54-87/2/861022f739fec5cb7bf01b26604e5a45 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30049 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1383883&dopt=citation | en_US |
dc.description.abstract | The purpose of the present study is to clarify the effect of clonidine on the release of serotonin from the rat hippocampus in vivo. For this purpose, endogenous serotonin release was measured by brain microdialysis. Potassium-evoked serotonin release from the hippocampus of freely moving rats was significantly inhibited when clonidine (10-5 M) was added to the perfusion solution, while the 5-hydroxyindoleacetic acid output remained unchanged. In catecholaminergically denervated rats, clonidine (10-5 M) also inhibited the potassium-evoked serotonin release from the hippocampus and the 5-hydroxyindoleacetic acid output was unaffected by clonidine. These results suggest that the inhibitory effect of clonidine on serotonin release from the hippocampus might reflect the activation of [alpha]2-adrenoceptors which are localized on the serotonergic nerve terminals. | en_US |
dc.format.extent | 297051 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109-0626, USA | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.contributor.affiliationother | First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan | en_US |
dc.identifier.pmid | 1383883 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30049/1/0000417.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(92)90857-4 | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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