Galanin inhibits rat pancreatic amylase release via cholinergic suppression
dc.contributor.author | Flowe, Kenneth M. | en_US |
dc.contributor.author | Lally, Kathleen M. | en_US |
dc.contributor.author | Mulholland, Michael W. | en_US |
dc.date.accessioned | 2006-04-10T15:14:57Z | |
dc.date.available | 2006-04-10T15:14:57Z | |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Flowe, Kenneth M., Lally, Kathleen M., Mulholland, Michael W. (1992)."Galanin inhibits rat pancreatic amylase release via cholinergic suppression." Peptides 13(3): 487-492. <http://hdl.handle.net/2027.42/30085> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0M-47T2WDT-C6/2/c6493d2f2667b23dc76663671eed6d38 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30085 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1381828&dopt=citation | en_US |
dc.description.abstract | The effects of galanin on pancreatic exocrine function were examined using rat pancreatic tissues. In anesthetized rats, galanin (40 [mu]g/kg/h) decreased amylase secretion stimulated by 2-deoxy glucose (5.8 +/- 0.1 vs. 3.1 +/- 0.1 times basal) and cholecystokinin octapeptide (21.5 +/- 0.6 vs. 16.8 +/- 0.5), while not inhibiting bethanechol-stimulated secretion. In dispersed acini, there was no effect of galanin alone (10-8 to 10-13 M) on amylase release, nor did galanin (10-6 or 10-8 M) coincubation affect amylase release stimulated by bethanechol (10-3 to 10-7 M) or CCK-8 (10-8 to 10-13 M). Using pancreatic lobules, coincubation with galanin (10-6 M) suppressed 75 mM KCl-stimulated amylase secretion and ACh release (10.1 +/- 0.6% vs. 7.3 +/- 0.4%). Veratridine-stimulated (10-4 M) amylase secretion and ACh release (12.4 +/- 1.7% vs. 8.5 +/- 0.7%) were similarly diminished. | en_US |
dc.format.extent | 624994 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Galanin inhibits rat pancreatic amylase release via cholinergic suppression | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 1381828 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30085/1/0000456.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0196-9781(92)90079-I | en_US |
dc.identifier.source | Peptides | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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