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The effect of myo-inositol treatment on basement membrane thickening in the BB/W-rat retina
dc.contributor.authorChakrabarti, Subrataen_US
dc.contributor.authorSima, Anders A. F.en_US
dc.date.accessioned2006-04-10T15:16:03Z
dc.date.available2006-04-10T15:16:03Z
dc.date.issued1992-04en_US
dc.identifier.citationChakrabarti, Subrata, Sima, Anders A. F. (1992/04)."The effect of myo-inositol treatment on basement membrane thickening in the BB/W-rat retina." Diabetes Research and Clinical Practice 16(1): 13-17. <http://hdl.handle.net/2027.42/30112>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T5Y-4BY4YSF-8S/2/f084eccc08e0ec30365ebaafdea12b16en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30112
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1576927&dopt=citationen_US
dc.description.abstractA polyol-pathway related perturbation of myo-inositol metabolism has been invoked in the pathogenesis of diabetic complications, including retinal microvasculopathy. Previous studies have demonstrated a beneficiary effect of aldose reductase inhibition on basement membrane thickening of retinal microvessels in diabetic animals. In the present study we demonstrate a significant but partial effect on basement membrane thickening following myo-inositol supplementation. Qualitative structural changes, such as nodular swellings, fibrillar changes and basement membrane projections were not effected by myo-inositol supplementation, suggesting that although abnormal myo-inositol tissue levels may play a role in basement membrane thickening, other factors may be of primary pathogenetic importance.en_US
dc.format.extent432437 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe effect of myo-inositol treatment on basement membrane thickening in the BB/W-rat retinaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor, MI, USA.en_US
dc.contributor.affiliationotherDepartment of Pathology, University of Manitoba, Winnipeg, MB, Canadaen_US
dc.identifier.pmid1576927en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30112/1/0000486.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0168-8227(92)90130-Jen_US
dc.identifier.sourceDiabetes Research and Clinical Practiceen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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