An SV40 transformation revertant due to a host mutation: Isolation and complementation analysis
dc.contributor.author | Silverstein, Gary H. | en_US |
dc.contributor.author | Kohrman, David C. | en_US |
dc.contributor.author | Christensen, Joan B. | en_US |
dc.contributor.author | Brockman, William W. | en_US |
dc.contributor.author | Imperiale, Michael J. | en_US |
dc.date.accessioned | 2006-04-10T15:17:11Z | |
dc.date.available | 2006-04-10T15:17:11Z | |
dc.date.issued | 1992-04 | en_US |
dc.identifier.citation | Silverstein, Gary H., Kohrman, David C., Christensen, Joan B., Brockman, William W., Imperiale, Michael J. (1992/04)."An SV40 transformation revertant due to a host mutation: Isolation and complementation analysis." Virology 187(2): 723-733. <http://hdl.handle.net/2027.42/30140> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXR-4BNVHHH-DF/2/85e300cb1507612444e26045500c2494 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30140 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1312274&dopt=citation | en_US |
dc.description.abstract | We have isolated an SV40 transformation revertant cell line, CLi L, by selection for normal cells whose growth is inhibited under low serum conditions. This line expresses a single, wild-type copy of large T antigen, yet is not transformed. It is not retransformable by transfection of SV40 DNA or infection with a recombinant retrovirus encoding large T antigen. Resistance to transformation therefore appears to be due to a cellular mutation. Fusion of CL1 L cells to normal 3T3 cells or SV40-transformed cells results in somatic cell hybrids that are transformed, indicating that resistance is recessive. In addition, fusion of CL1L cells to another SV40 transformation-resistant line, A27, results in transformed hybrids, indicating the existence of discrete complementation groups with respect to SV40 transformation. | en_US |
dc.format.extent | 7651520 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | An SV40 transformation revertant due to a host mutation: Isolation and complementation analysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA. | en_US |
dc.contributor.affiliationum | Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109-0620, USA. | en_US |
dc.identifier.pmid | 1312274 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30140/1/0000517.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0042-6822(92)90475-5 | en_US |
dc.identifier.source | Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.