Effect of coronary stenosis severity on variability of quantitative arteriography, and implications for interventional trials
dc.contributor.author | Mancini, G. B. John | en_US |
dc.contributor.author | Williamson, Paula R. | en_US |
dc.contributor.author | DeBoe, Scott F. | en_US |
dc.date.accessioned | 2006-04-10T15:17:40Z | |
dc.date.available | 2006-04-10T15:17:40Z | |
dc.date.issued | 1992-03-15 | en_US |
dc.identifier.citation | Mancini, G. B. John, Williamson, Paula R., DeBoe, Scott F. (1992/03/15)."Effect of coronary stenosis severity on variability of quantitative arteriography, and implications for interventional trials." The American Journal of Cardiology 69(8): 806-807. <http://hdl.handle.net/2027.42/30152> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T10-4C708BS-B3/2/2b7b3eccc6eff107dfb602b819d8e4a8 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30152 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1546658&dopt=citation | en_US |
dc.description.abstract | Quantitative coronary arteriography is now routinely used in studies assessing arterial remodelling in response to interventions such as lipid lowering and percutaneous transluminal coronary angioplasty. Although this methodology provides both relative and absolute measurements that can be evaluated statistically as continuous variables, it is, however, often desirable or necessary to establish categorical responses to the interventions based on the variability inherent in the quantitative methods (i.e., it is often necessary to state whether individual patients, as opposed to entire groups, have "restenosed," "progressed," "regressed," and so forth, and these categorical designations are based on critical limits of variability). 1,2 These limits are generally based on an analysis of a rather diverse range of lesion severity, and the question arises as to whether the variability of measuring changes in lesion or segment morphology is affected by the initial severity of the lesion being studied. It is conceivable that variability may be greater at 1 end than at the other end of the spectrum of lesion severity. If this is true, then the use of 1 critical value to designate whether a subject has responded in a certain way would be inappropriate, and this designation would be better achieved by using criteria that more directly reflect the measurement variability of lesions of a specified, initial severity. This report examines whether the variability of measuring morphologic parameters of stenoses is affected by the baseline severity of the lesion. | en_US |
dc.format.extent | 259896 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Effect of coronary stenosis severity on variability of quantitative arteriography, and implications for interventional trials | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Cardiology, University of Michigan and Veterans Administration Medical Centers (111A), 2215 Fuller Road, Ann Arbor, Michigan 48105, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Cardiology, University of Michigan and Veterans Administration Medical Centers (111A), 2215 Fuller Road, Ann Arbor, Michigan 48105, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Cardiology, University of Michigan and Veterans Administration Medical Centers (111A), 2215 Fuller Road, Ann Arbor, Michigan 48105, USA | en_US |
dc.identifier.pmid | 1546658 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30152/1/0000529.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9149(92)90510-6 | en_US |
dc.identifier.source | The American Journal of Cardiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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