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An improved method of in vivo wound disruption and measurement

dc.contributor.authorCharles, Daviden_US
dc.contributor.authorWilliams, III, Kirken_US
dc.contributor.authorPerry, Larry C.en_US
dc.contributor.authorFisher, Jacken_US
dc.contributor.authorRees, Riley S.en_US
dc.date.accessioned2006-04-10T15:18:38Z
dc.date.available2006-04-10T15:18:38Z
dc.date.issued1992-03en_US
dc.identifier.citationCharles, David, Williams, III, Kirk, Perry, Larry C., Fisher, Jack, Rees, Riley S. (1992/03)."An improved method of in vivo wound disruption and measurement." Journal of Surgical Research 52(3): 214-218. <http://hdl.handle.net/2027.42/30176>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WM6-4BNF1SJ-1PD/2/ddcc17e2a3f8cbeb045e409414d9dfdeen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30176
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1538596&dopt=citationen_US
dc.description.abstractBiomechanical studies of wound strength are important because of new investigations in growth factors, cytokines, and fetal wounds. We compared two traditional methods of wound disruption measurement with a novel computerized model designed for in vivo experiments. An Instron tensiometer (INSTS) and an air insufflated positive pressure device (AIPPD) were compared with a vacuum-controlled wound chamber device (VCWCD). The VCWCD produced vacuum at the wound site and wound disruption was monitored with two video camera/recorders. Rats were marked with a template guide for a 2.5 cm, full-thickness, abdominal incisional wound. Rats were divided into three groups and studied at 2, 7, or 14 days after wounding. The recorded images were computer digitalized to generate wound strength curves from a three-dimensional model. A comparison of the wound disruption curves demonstrated that the VCWCD was comparable to the INST or AIPPD in normal wound healing (P&gt; .40). The VCWCD provided data with less standard error at 2 days after wounding (P P in vivo method which required minimal wound manipulation.en_US
dc.format.extent680127 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleAn improved method of in vivo wound disruption and measurementen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Section of Plastic and Reconstructive Surgery, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherVanderbilt University School of Medicine, Nashville, Tennessee, USAen_US
dc.contributor.affiliationotherVanderbilt University School of Medicine, Nashville, Tennessee, USAen_US
dc.contributor.affiliationotherThe Reconstructive Surgery Foundation, Nashville, Tennessee, USAen_US
dc.contributor.affiliationotherThe Reconstructive Surgery Foundation, Nashville, Tennessee, USAen_US
dc.identifier.pmid1538596en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30176/1/0000561.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0022-4804(92)90076-Cen_US
dc.identifier.sourceJournal of Surgical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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