An improved method of in vivo wound disruption and measurement
dc.contributor.author | Charles, David | en_US |
dc.contributor.author | Williams, III, Kirk | en_US |
dc.contributor.author | Perry, Larry C. | en_US |
dc.contributor.author | Fisher, Jack | en_US |
dc.contributor.author | Rees, Riley S. | en_US |
dc.date.accessioned | 2006-04-10T15:18:38Z | |
dc.date.available | 2006-04-10T15:18:38Z | |
dc.date.issued | 1992-03 | en_US |
dc.identifier.citation | Charles, David, Williams, III, Kirk, Perry, Larry C., Fisher, Jack, Rees, Riley S. (1992/03)."An improved method of in vivo wound disruption and measurement." Journal of Surgical Research 52(3): 214-218. <http://hdl.handle.net/2027.42/30176> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNF1SJ-1PD/2/ddcc17e2a3f8cbeb045e409414d9dfde | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30176 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1538596&dopt=citation | en_US |
dc.description.abstract | Biomechanical studies of wound strength are important because of new investigations in growth factors, cytokines, and fetal wounds. We compared two traditional methods of wound disruption measurement with a novel computerized model designed for in vivo experiments. An Instron tensiometer (INSTS) and an air insufflated positive pressure device (AIPPD) were compared with a vacuum-controlled wound chamber device (VCWCD). The VCWCD produced vacuum at the wound site and wound disruption was monitored with two video camera/recorders. Rats were marked with a template guide for a 2.5 cm, full-thickness, abdominal incisional wound. Rats were divided into three groups and studied at 2, 7, or 14 days after wounding. The recorded images were computer digitalized to generate wound strength curves from a three-dimensional model. A comparison of the wound disruption curves demonstrated that the VCWCD was comparable to the INST or AIPPD in normal wound healing (P> .40). The VCWCD provided data with less standard error at 2 days after wounding (P P in vivo method which required minimal wound manipulation. | en_US |
dc.format.extent | 680127 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | An improved method of in vivo wound disruption and measurement | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Section of Plastic and Reconstructive Surgery, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Vanderbilt University School of Medicine, Nashville, Tennessee, USA | en_US |
dc.contributor.affiliationother | Vanderbilt University School of Medicine, Nashville, Tennessee, USA | en_US |
dc.contributor.affiliationother | The Reconstructive Surgery Foundation, Nashville, Tennessee, USA | en_US |
dc.contributor.affiliationother | The Reconstructive Surgery Foundation, Nashville, Tennessee, USA | en_US |
dc.identifier.pmid | 1538596 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30176/1/0000561.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(92)90076-C | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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