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A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice
dc.contributor.authorSweet, Ann M.en_US
dc.contributor.authorErickson, Robert P.en_US
dc.contributor.authorHuntington, Caleben_US
dc.contributor.authorDawson, David C.en_US
dc.date.accessioned2006-04-10T15:20:25Z
dc.date.available2006-04-10T15:20:25Z
dc.date.issued1992-02en_US
dc.identifier.citationSweet, Ann, Erickson, Robert P., Huntington, Caleb, Dawson, David (1992/02)."A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice." Biochemical Medicine and Metabolic Biology 47(1): 97-102. <http://hdl.handle.net/2027.42/30220>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBN-4C4NS9N-22/2/ae05a1d4ec16fad44002f329367f3a81en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30220
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1562359&dopt=citationen_US
dc.description.abstractWe have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA/2J than in the C57BL/6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL/6J parental strain while colonic segments from five recombinant inbred B x D lines ranged between the C57BL/6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.en_US
dc.format.extent437708 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleA potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of miceen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA; Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.en_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Physiology University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USAen_US
dc.identifier.pmid1562359en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30220/1/0000612.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0885-4505(92)90011-Men_US
dc.identifier.sourceBiochemical Medicine and Metabolic Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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