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Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of [beta]-glucosidase inhibition
dc.contributor.authorMahdiyoun, Shahryaren_US
dc.contributor.authorDeshmukh, Gayatri D.en_US
dc.contributor.authorAbe, Akiraen_US
dc.contributor.authorRadin, Norman S.en_US
dc.contributor.authorShayman, James A.en_US
dc.date.accessioned2006-04-10T15:21:10Z
dc.date.available2006-04-10T15:21:10Z
dc.date.issued1992-02-01en_US
dc.identifier.citationMahdiyoun, Shahryar, Deshmukh, Gayatri D., Abe, Akira, Radin, Norman S., Shayman, James A. (1992/02/01)."Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of [beta]-glucosidase inhibition." Archives of Biochemistry and Biophysics 292(2): 506-511. <http://hdl.handle.net/2027.42/30238>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WB5-4DNB080-17P/2/fd6afeba6c9df78d285368f5f94043b3en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30238
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1731615&dopt=citationen_US
dc.description.abstractRecent work has demonstrated the enhancement of hormone-stimulated inositol trisphosphate formation in renal epithelial cells under conditions of glucosylceramide depletion. The role of glucosylceramide metabolism was explored further by exposing Madin-Darby canine kidney (MDCK) cells to the [beta]-glucosidase inhibitor conduritol B epoxide, which produced time-dependent and concentration-dependent increases in glucosylceramide levels and decreased bradykinin-stimulated inositol trisphosphate formation from isolated MDCK cell membranes. These data provide further support for an association between glucosylceramide levels and hormone-stimulated inositol trisphosphate formation.en_US
dc.format.extent973029 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleDecreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of [beta]-glucosidase inhibitionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0676, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0676, U.S.A.en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0676, U.S.A.en_US
dc.contributor.affiliationumMental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0676, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0676, U.S.A.en_US
dc.identifier.pmid1731615en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30238/1/0000632.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0003-9861(92)90023-Pen_US
dc.identifier.sourceArchives of Biochemistry and Biophysicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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