Glutamic acid-insensitive [3H]kainic acid binding in goldfish brain
dc.contributor.author | Davis, Roger E. | en_US |
dc.contributor.author | Wilmot, George R. | en_US |
dc.contributor.author | Cha, Jang-Ho J. | en_US |
dc.date.accessioned | 2006-04-10T15:21:15Z | |
dc.date.available | 2006-04-10T15:21:15Z | |
dc.date.issued | 1992-01-31 | en_US |
dc.identifier.citation | Davis, Roger E., Wilmot, George R., Cha, Jang-Ho J. (1992/01/31)."Glutamic acid-insensitive [3H]kainic acid binding in goldfish brain." Brain Research 571(1): 73-78. <http://hdl.handle.net/2027.42/30240> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-483SMGY-JK/2/ca4c36135be4795dd8499e39abb25b24 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30240 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1377085&dopt=citation | en_US |
dc.description.abstract | Kainic acid is supposed to be a specific agonist for a subclass of excitatory glutamate receptors in the vertebrate CNS. An investigation of (2 nM) [3H]kainic acid binding sites in goldfish brain, using quantitative autoradiography, has revealed evidence for two types of kainic acid receptors which differ in sensitivity to glutamic acid. -Glutamic acid (0.1-1 mM) displaced over 95% of specific [3H]kainic acid binding elsewhere in the brain but only 10-50% in the cerebellum and cerebellar crest. These structures apparently contain [3H]kainic acid binding sites that are extremely insensitive to glutamic acid. The glutamic acid-insensitive [3H]kainic acid bindings was not displaced by quisqualic acid kynurenic acid, [alpha]-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA), or , but was completely displaced by the kainic acid analogue domoic acid. The data indicate that two types of high affinity binding sites for [3H]kainic acid exist in the goldfish brain: glutamic acid-sensitive and glutamic acid-insensitive. High affinity [3H]kainic acid binding may therefore not always represent binding to subsets of glutamic acid receptors. | en_US |
dc.format.extent | 1019149 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Glutamic acid-insensitive [3H]kainic acid binding in goldfish brain | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Neuroscience Program, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Neuroscience Program, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.contributor.affiliationum | Mental Health Research Institute and Neuroscience Program, The University of Michigan, Ann Arbor, MI 48104-1687, U.S.A. | en_US |
dc.identifier.pmid | 1377085 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30240/1/0000634.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(92)90510-G | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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