Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor,
dc.contributor.author | Kokudo, Norihiro | en_US |
dc.contributor.author | Kothary, ]piyush C. | en_US |
dc.contributor.author | Eckhauser, Frederic E. | en_US |
dc.contributor.author | Nakamura, Toshikazu | en_US |
dc.contributor.author | Raper, Steven E. | en_US |
dc.date.accessioned | 2006-04-10T15:24:33Z | |
dc.date.available | 2006-04-10T15:24:33Z | |
dc.date.issued | 1992-01 | en_US |
dc.identifier.citation | Kokudo, Norihiro, Kothary, ]Piyush C., Eckhauser, Frederic E., Nakamura, Toshikazu, Raper, Steven E. (1992/01)."Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor,." The American Journal of Surgery 163(1): 169-173. <http://hdl.handle.net/2027.42/30314> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6VHS-4BX2FWP-VG/2/d2ba74ee7d7ea083bceb3a6c0eee7064 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30314 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1346360&dopt=citation | en_US |
dc.description.abstract | The antiproliferative effects of somatostatin on hepatocytes stimulated by hepatocyte growth factor (HGF) or epidermal growth factor (EGF) were investigated using primary cultures of adult rat hepatocytes. Somatostatin inhibits HGF-induced (at a dose of 10 ng/mL) or EGF-induced (at a dose of 100 ng/mL) 3H-thymidine incorporation into hepatocytes in a dose-dependent manner (10-10 to 10-8 M). This inhibition was confirmed by autoradiography. The effect of somatostatin was nontoxic as judged by preserved albumin synthesis, a marker for differentiated hepatocyte function. In the presence or absence of somatostatin, neither HGF nor EGF significantly altered intracellular cyclic adenosine monophosphate (cAMP). We conclude that somatostatin is a potent inhibitor of HGF-or EGF-induced deoxyribonucleic acid synthesis in adult rat hepatocytes. The mechanism of this inhibition appears to be independent of cAMP. The significance of somatostatin in liver regeneration has yet to be | en_US |
dc.format.extent | 714707 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Inhibition of DNA synthesis by somatostatin in rat hepatocytes stimulated by hepatocyte growth factor or epidermal growth factor, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | From the Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | From the Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | From the Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | From the Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | From the Department of Biology, Kyushu University, Fukuoka, Japan | en_US |
dc.identifier.pmid | 1346360 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30314/1/0000716.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9610(92)90271-R | en_US |
dc.identifier.source | The American Journal of Surgery | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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