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Stimulation of myenteric plexus neurite outgrowth by insulin and insulin-like growth factors I and II
dc.contributor.authorMulholland, Michael W.en_US
dc.contributor.authorRomanchuk, Gailen_US
dc.contributor.authorSimeone, Diane M.en_US
dc.contributor.authorFlowe, Kenneth M.en_US
dc.date.accessioned2006-04-10T15:26:54Z
dc.date.available2006-04-10T15:26:54Z
dc.date.issued1992en_US
dc.identifier.citationMulholland, Michael W., Romanchuk, Gail, Simeone, Dianee M., Flowe, Kenneth (1992)."Stimulation of myenteric plexus neurite outgrowth by insulin and insulin-like growth factors I and II." Life Sciences 51(23): 1789-1796. <http://hdl.handle.net/2027.42/30371>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T99-477GDJF-DP/2/4ebd59a63295eab69f1ba64ffa6053dden_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30371
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1435087&dopt=citationen_US
dc.description.abstractA defined culture medium containing insulin, insulin-like growth factor I (IGF-I) or insulin-like growth II (IGF-II) supported morphological development of myenteric plexus neurons derived from neonatal guinea pigs. Insulin increased neurite outgrowth 3-fold at concentrations as low as 0.2 nM. Similar significant and dose-dependent increases in neurite outgrowth were noted with IGF-I and IGF-II. Stimulation of neurite outgrowth was abolished by exposure to cytosine arabinofuranoside, an agent toxic to non-neuronal cells, implying that trophic effects of insulin or insulin-like growth factors require the presence of non-neuronal elements in culture.en_US
dc.format.extent414140 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleStimulation of myenteric plexus neurite outgrowth by insulin and insulin-like growth factors I and IIen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMichigan Gastrointestinal Peptide Center, 2922 D Taubman, University of Michigan, Ann Arbor, Michigan 48109-0331, USAen_US
dc.contributor.affiliationumMichigan Gastrointestinal Peptide Center, 2922 D Taubman, University of Michigan, Ann Arbor, Michigan 48109-0331, USAen_US
dc.contributor.affiliationumMichigan Gastrointestinal Peptide Center, 2922 D Taubman, University of Michigan, Ann Arbor, Michigan 48109-0331, USAen_US
dc.contributor.affiliationumMichigan Gastrointestinal Peptide Center, 2922 D Taubman, University of Michigan, Ann Arbor, Michigan 48109-0331, USAen_US
dc.identifier.pmid1435087en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30371/1/0000773.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0024-3205(92)90049-Uen_US
dc.identifier.sourceLife Sciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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