Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis
dc.contributor.author | Simmons, Zachary | en_US |
dc.contributor.author | Blaivas, Mila | en_US |
dc.contributor.author | Aguilera, Arnold J. | en_US |
dc.contributor.author | Feldman, Eva L. | en_US |
dc.contributor.author | Bromberg, Mark B. | en_US |
dc.contributor.author | Towfighi, Javad | en_US |
dc.date.accessioned | 2006-04-10T15:28:36Z | |
dc.date.available | 2006-04-10T15:28:36Z | |
dc.date.issued | 1993-12-01 | en_US |
dc.identifier.citation | Simmons, Zachary, Blaivas, Mila, Aguilera, Arnold J., Feldman, Eva L., Bromberg, Mark B., Towfighi, Javad (1993/12/01)."Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis." Journal of the Neurological Sciences 120(1): 60-63. <http://hdl.handle.net/2027.42/30401> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T06-485YBS7-47/2/c57552be621969996723a650fc3d137f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30401 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7507161&dopt=citation | en_US |
dc.description.abstract | Patients with primary amyloidosis may develop peripheral neuropathy as an early feature. Sural nerve biopsy is reported to be a sensitive method for diagnosing amyloidosis in such patients. We identified nine patients, ultimately diagnosed as having amyloidosis, who were referred for peripheral neuropathy of undetermined etiology. In six, a sural nerve biopsy demonstrated no amyloid. Subsequent examination of other tissue or of the contralateral sural nerve eventually resulted in the correct diagnosis. We conclude that sural nerve biopsy may be less sensitive than previously believed for the diagnosis of amyloidosis in patients with peripheral neuropathy secondary to amyloid. When the clinical suspicion of amyloidosis is high, a nondiagnostic sural nerve biopsy should not discourage the performance of further investigative studies. | en_US |
dc.format.extent | 317352 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Neurology, Geisinger Medical Center, Danville, PA 17822, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, PA 17033, USA | en_US |
dc.identifier.pmid | 7507161 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30401/1/0000021.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-510X(93)90025-T | en_US |
dc.identifier.source | Journal of the Neurological Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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