Fibrillin genes map to regions of conserved mouse/human syntenyon mouse chromosomes 2 and 18
dc.contributor.author | Li, Xu | en_US |
dc.contributor.author | Pereira, Lygia | en_US |
dc.contributor.author | Zhang, Hui | en_US |
dc.contributor.author | Sanguineti, Chiara | en_US |
dc.contributor.author | Ramirez, Francesco | en_US |
dc.contributor.author | Bonadio, Jeffrey F. | en_US |
dc.contributor.author | Francke, Uta | en_US |
dc.date.accessioned | 2006-04-10T15:29:28Z | |
dc.date.available | 2006-04-10T15:29:28Z | |
dc.date.issued | 1993-12 | en_US |
dc.identifier.citation | Li, Xu, Pereira, Lygia, Zhang, Hui, Sanguineti, Chiara, Ramirez, Francesco, Bonadio, Jeffrey, Francke, Uta (1993/12)."Fibrillin genes map to regions of conserved mouse/human syntenyon mouse chromosomes 2 and 18." Genomics 18(3): 667-672. <http://hdl.handle.net/2027.42/30422> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4H2P71C-K/2/e573532b51b4c1c6e2ed25ad996a9d75 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30422 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8307578&dopt=citation | en_US |
dc.description.abstract | Fibrillin proteins are major structural components of the 10-nm microfibrils found in elastic and nonelastic connective tissues. Previous studies have mapped the human genes for two fibrillins to chromosome bands 15q21 (FBN1) and 5823-q31 (FBN2) and have demonstrated that FBN1 mutations are associated with Marfan syndrome, while FBN2 is linked to the gene for congenital contractural arachnodactyly. Here, we report the isolation of genomic clones of the corresponding mouse fibrillin genes (Fbn-1 and Fbn-2). By analyzing a mapping panel of mouse × rodent somatic hybrid cell lines, we have assigned the Fbn-1 gene to mouse chromosome 2 and the Fbn-2 gene to mouse chromosome 18. We then sublocalized the fibrillin genes to bands 2F (Fbn-1) and 18D-E1 (Fbn-2) by fluorescence in situ hybridization. These regions are known to exhibit conserved synteny with the regions on human chromosomes 15 and 5 that carry the homologous human fibrillin genes. In addition, the Fbn-1 gene maps in the vicinity of the gene for a connective tissue disorder on mouse chromosome 2 called Tight-skin (Tsk). | en_US |
dc.format.extent | 985304 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Fibrillin genes map to regions of conserved mouse/human syntenyon mouse chromosomes 2 and 18 | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USA | en_US |
dc.contributor.affiliationother | Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, California 94305-5428, USA | en_US |
dc.contributor.affiliationother | Brookdale Center for Molecular Biology, The Mount Sinai School of Medicine,One Gustave L. Levy Place, New York, New York 10029-6574, USA | en_US |
dc.contributor.affiliationother | Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, California 94305-5428, USA; Departments of Genetics and Pediatrics, Stanford University Medical Center, Stanford,California 94305-5428, USA. | en_US |
dc.identifier.pmid | 8307578 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30422/1/0000043.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0888-7543(05)80371-4 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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