Degradation of polyurethanes in vitro and in vitro: comparison of different models
dc.contributor.author | Frautschi, Jack R. | en_US |
dc.contributor.author | Chinn, Joseph A. | en_US |
dc.contributor.author | Phillips, Jr. , Richard E. | en_US |
dc.contributor.author | Zhao, Q. H. | en_US |
dc.contributor.author | Anderson, James M. | en_US |
dc.contributor.author | Joshi, Ravi R. | en_US |
dc.contributor.author | Levy, Robert J. | en_US |
dc.date.accessioned | 2006-04-10T15:30:46Z | |
dc.date.available | 2006-04-10T15:30:46Z | |
dc.date.issued | 1993-11-08 | en_US |
dc.identifier.citation | Frautschi, Jack R., Chinn, Joseph A., Phillips, Jr., Richard E., Zhao, Q. H., Anderson, James M., Joshi, Ravi, Levy, Robert J. (1993/11/08)."Degradation of polyurethanes in vitro and in vitro: comparison of different models." Colloids and Surfaces B: Biointerfaces 1(5): 305-313. <http://hdl.handle.net/2027.42/30454> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TFS-44FMN24-10/2/e7b53ee85fb92b235fca02e4fe395625 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30454 | |
dc.description.abstract | This study compares and contrasts mechanisms of polyetherurethane (PEU) degradation in vitro and in vivo. Models comprising incubation with hydrogen peroxide in vitro (H2O2), in vivo subcutaneous rat implant (SUBQ), and subcutaneous rat cage implant (CAGE) are described and compared with in vivo degradation of the pacemaker lead device retrieved after human implant (PACE). Experimental results support the hypothesis that stress accelerates PEU degradation. Scanning electron microscopy (SEM), gel permeation chromatography (GPC), and Fourier transform IR spectroscopy/attenuated total reflectance (FT-1R/ATR) evaluation of tested PEU samples suggests, for all models, decreased soft segment and increased ester functionality at the polymer surface. These observations are consistent with a single, metal ion catalyzed, polyester intermediate, oxidative degradation mechanism common to all models, and with device performance in vivo. Model comparison suggests that in vitro H2O2 and in vivo SUBQ and CAGE models accurately mimic in vivo degradation of the pacemaker lead device (PACE). | en_US |
dc.format.extent | 962141 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Degradation of polyurethanes in vitro and in vitro: comparison of different models | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109-0576, USA | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109-0576, USA | en_US |
dc.contributor.affiliationother | CarboMedics, 1300 B East Anderson Lane, Austin, TX 78752-1793, USA | en_US |
dc.contributor.affiliationother | CarboMedics, 1300 B East Anderson Lane, Austin, TX 78752-1793, USA | en_US |
dc.contributor.affiliationother | CarboMedics, 1300 B East Anderson Lane, Austin, TX 78752-1793, USA | en_US |
dc.contributor.affiliationother | Departments of Macromolecular Science and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA | en_US |
dc.contributor.affiliationother | Departments of Macromolecular Science and Pathology, Case Western Reserve University, Cleveland, OH 44106, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30454/1/0000080.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0927-7765(93)80005-J | en_US |
dc.identifier.source | Colloids and Surfaces B: Biointerfaces | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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