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Molecular Characterization of the Murine Neural Retina Leucine Zipper Gene, Nrl
dc.contributor.authorFarjo, Qaisen_US
dc.contributor.authorJackson, Anne U.en_US
dc.contributor.authorXu, Junzheen_US
dc.contributor.authorGryzenia, Micheleen_US
dc.contributor.authorSkolnick, Craigen_US
dc.contributor.authorAgarwal, Neerajen_US
dc.contributor.authorSwaroop, Ananden_US
dc.date.accessioned2006-04-10T15:31:19Z
dc.date.available2006-04-10T15:31:19Z
dc.date.issued1993-11en_US
dc.identifier.citationFarjo, Qais, Jackson, Anne U., Xu, Junzhe, Gryzenia, Michele, Skolnick, Craig, Agarwal, Neeraj, Swaroop, Anand (1993/11)."Molecular Characterization of the Murine Neural Retina Leucine Zipper Gene, Nrl." Genomics 18(2): 216-222. <http://hdl.handle.net/2027.42/30468>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-45PMR13-7/2/1ac5b5c0adb59cb0be7f0856377d8fecen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30468
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8288222&dopt=citationen_US
dc.description.abstractThe NRL gene (D14S46E) is expressed in cells of human retina and encodes a putative DNA-binding protein of the leucine zipper family. Here we describe the analysis of the murine homolog of the NRL gene, Nrl. Various cDNAs resulting from alternate polyadenylation are characterized. The deduced polypeptide sequence is highly conserved between mouse and human, with an identical basic motif and leucine zipper domain. The nucleotide sequences in the 5' and 3'-untranslated regions also show significant homology. The 3'-untranslated region contains a polymorphic AGG- trinucleotide repeat. The murine Nrl gene consists of three exons; of these, the first is untranslated. The 5'-upstream promoter region has no canonical TATA box, but contains consensus binding site sequences for several DNA-binding proteins. Analysis of RNA from adult mouse tissues confirms the retina-specific expression of Nrl. This study provides the basis for dissecting the cis -regulatory elements involved in the retina-specific expression and for the development of an experimental model to investigate the function or any diseases associated with this gene in humans.en_US
dc.format.extent440570 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMolecular Characterization of the Murine Neural Retina Leucine Zipper Gene, Nrlen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationumDepartment of Human Genetics, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationumDepartment of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationumDepartment of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationumDepartment of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationumDepartments of Ophthalmology and Human Genetics, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105en_US
dc.contributor.affiliationotherDepartment of Anatomy and Cell Biology and North Texas Eye Research Institute, Texas College of Osteopathic Medicine, Fort Worth, Texas 76107en_US
dc.identifier.pmid8288222en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30468/1/0000096.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1006/geno.1993.1458en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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