Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus
dc.contributor.author | Schwartz, Donald R. | en_US |
dc.contributor.author | Schacht, Jochen | en_US |
dc.contributor.author | Miller, Josef M. | en_US |
dc.contributor.author | Frey, Kirk A. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.date.accessioned | 2006-04-10T15:31:27Z | |
dc.date.available | 2006-04-10T15:31:27Z | |
dc.date.issued | 1993-11 | en_US |
dc.identifier.citation | Schwartz, Donald R., Schacht, Jochen, Miller, Josef M., Frey, Kirk, Altschuler, Richard A. (1993/11)."Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus." Hearing Research 70(2): 243-249. <http://hdl.handle.net/2027.42/30471> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-487CV5R-3N/2/5beed903108cc2085539c30fc5412e67 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30471 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8294268&dopt=citation | en_US |
dc.description.abstract | The [14C]-2-deoxyglucose (2-DG) autoradiographic technique was used to study how auditory-related metabolic activity changes with deafness, and how chronic electrical stimulation of the deafened system may modify these changes. Guinea pigs were deafened by administration of kanamycin and ethacrynic acid. After nine weeks of deafness, the basal unstimulated uptake of 2-DG in the inferior colliculus (IC) was lower than in normal hearing control animals. 100 [mu]A of acute cochlear electrical stimulation significantly increased 2-DG uptake in normal hearing animals but did not evoke a significant increase in four or nine week deafened animals. Electrically elicited 2-DG uptake in the IC is therefore depressed by prolonged deafness. In a second series of experiments, after four weeks of deafness, animals were chronically electrically stimulated via a cochlear implant 2.5-3.5 h a day, five days a week for five weeks at 100 [mu],A. Acute cochlear electrical stimulation following this chronic stimulation significantly increased 2-DG uptake in the contralateral IC over unstimulated levels. This suggests that some depressive effects of profound deafness on the auditory brain stem may be reduced or reversed with chronic electrical stimulation by a cochlear implant. | en_US |
dc.format.extent | 823145 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Neurology, University of Michigan, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI 48109, USA | en_US |
dc.identifier.pmid | 8294268 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30471/1/0000099.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(93)90162-T | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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