TCDD alters pituitary-adrenal function II: Evidence for decreased bioactivity of ACTH
dc.contributor.author | Bestervelt, Lorelle L. | en_US |
dc.contributor.author | Pitt, Jeff A. | en_US |
dc.contributor.author | Nolan, Colleen J. | en_US |
dc.contributor.author | Piper, Walter N. | en_US |
dc.date.accessioned | 2006-04-10T15:31:54Z | |
dc.date.available | 2006-04-10T15:31:54Z | |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Bestervelt, Lorelle L., Pitt, Jeff A., Nolan, Colleen J., Piper, Walter N. (1993)."TCDD alters pituitary-adrenal function II: Evidence for decreased bioactivity of ACTH." Neurotoxicology and Teratology 15(6): 371-376. <http://hdl.handle.net/2027.42/30482> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T9X-47RWP06-9H/2/59234e95b730171340f42d55d0fe474e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30482 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8302237&dopt=citation | en_US |
dc.description.abstract | The present study assessed the ability of primary cultures of rat anterior pituitary cells to secrete bioactive ACTH in the presence of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). The bioactivity of the secreted pituitary cell ACTH was determined by its ability to stimulate secretion of corticosterone from primary cultures of rat adrenal cells. ACTH from basal or CRH stimulated pituitary cells treated with TCDD was found to be less capable of stimulating corticosterone secretion from primary rat adrenal cell cultures than equimolar concentrations of ACTH purchased from a commercial supplier. Corticosterone secretion from adrenal cell cultures treated with ACTH from basal or CRH stimulated pituitary cell cultures exposed to TCDD was decreased by 60 and 70%, respectively. The decreased ability to stimulate corticosterone secretion can be overcome when extracts of ACTH from pituitary cell cultures treated with TCDD are supplemented with commercial ACTH. These findings indicate that TCDD may alter the bioactivity of secreted ACTH from the anterior pituitary gland. | en_US |
dc.format.extent | 650696 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | TCDD alters pituitary-adrenal function II: Evidence for decreased bioactivity of ACTH | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Reproductive Sciences Program, Medical School, The University of Michigan, Ann Arbor, MI 48109-2029, USA; Toxicology Program, School of Public Health, The University of Michigan, Ann Arbor, MI 48109-2029, USA. | en_US |
dc.contributor.affiliationum | Reproductive Sciences Program, Medical School, The University of Michigan, Ann Arbor, MI 48109-2029, USA; Toxicology Program, School of Public Health, The University of Michigan, Ann Arbor, MI 48109-2029, USA. | en_US |
dc.contributor.affiliationum | Reproductive Sciences Program, Medical School, The University of Michigan, Ann Arbor, MI 48109-2029, USA; Toxicology Program, School of Public Health, The University of Michigan, Ann Arbor, MI 48109-2029, USA. | en_US |
dc.contributor.affiliationum | Reproductive Sciences Program, Medical School, The University of Michigan, Ann Arbor, MI 48109-2029, USA; Toxicology Program, School of Public Health, The University of Michigan, Ann Arbor, MI 48109-2029, USA; Department of Pharmacology, Medical School, The University of Michigan, Ann Arbor, MI 48109-2029, USA. | en_US |
dc.identifier.pmid | 8302237 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30482/1/0000110.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0892-0362(93)90053-Q | en_US |
dc.identifier.source | Neurotoxicology and Teratology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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